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Merck
CN

1.07478

1,2-Propanediol

EMPROVE® EXPERT, Ph. Eur., BP, USP, ChP

Synonym(s):

1,2-Propanediol, 1,2-Propylene glycol

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About This Item

Linear Formula:
CH3CH(OH)CH2OH
CAS Number:
Molecular Weight:
76.09
UNSPSC Code:
12352104
EC Index Number:
200-338-0
MDL number:
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Quality Level

agency

BP, ChP, Ph. Eur., USP

vapor pressure

0.11 hPa ( 20 °C)

product line

EMPROVE® EXPERT

assay

≥99.5% (GC)

form

liquid

autoignition temp.

371 °C

expl. lim.

2.4-17.4 % (v/v)

refractive index

n20/D 1.43

pH

6-8 (20 °C, 100 g/L in H2O)

bp

188 °C/1013 hPa

mp

-59 °C

transition temp

flash point 99 °C

density

1.04 g/cm3 at 20 °C

application(s)

liquid formulation
ophthalmics
parenterals
parenterals
pharmaceutical
semi-solid formulation

storage temp.

2-30°C

SMILES string

OC(CO)C

InChI

1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3

InChI key

DNIAPMSPPWPWGF-UHFFFAOYSA-N

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Propylene glycol is used as solvent in a variety of liquid formulations.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany


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Storage Class

10 - Combustible liquids

flash_point_f

219.2 °F - closed cup

flash_point_c

104 °C - closed cup



Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Articles

Medicine for children poses unique formulation challenges compared to adults. Consider developmental physiology and age specifics when designing pharmaceuticals. Quality issues can severely impact patient safety. Therefore, excipient quality, supplier selection, and supply chain security are crucial, particularly for pediatric formulations.

Related Content

Developing formulations specifically for infants and children is increasingly important. To help you master these challenges effectively, we offer an extensive portfolio of well-established high-quality excipients and APIs for pediatric pharmaceutical formulations that are proven in practice.





Global Trade Item Number

SKUGTIN
107478602504022536091167
107478619004022536091174
107478250004022536091136
107478919004022536091198