8.52005
Fmoc-Asp(OtBu)-OH
Novabiochem®
Synonym(s):
Fmoc-Asp(OtBu)-OH, N-α-Fmoc-L-aspartic acid β-t.-butyl ester
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About This Item
Quality Level
product line
Novabiochem®
assay
≥98% (TLC), ≥98.0% (acidimetric), ≥99.0% (HPLC)
form
powder
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename
Novabiochem®
mp
143-150 °C
application(s)
peptide synthesis
functional group
carboxylic acid
storage temp.
2-30°C
SMILES string
N([C@@H](CC(=O)OC(C)(C)C)C(=O)[O-])C(=O)OCC1c2c(cccc2)c3c1cccc3
InChI
1S/C23H25NO6/c1-23(2,3)30-20(25)12-19(21(26)27)24-22(28)29-13-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,12-13H2,1-3H3,(H,24,28)(H,26,27)/p-1/t19-/m0/s1
InChI key
FODJWPHPWBKDON-IBGZPJMESA-M
General description
Standard building block for introduction of aspartic acid amino-acid residues by Fmoc SPPS
Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Application
- Silybin liver research: Silybin A and B, as part of the silymarin complex, are extensively studied for their hepatoprotective properties. They play a crucial role in liver health by mitigating oxidative stress and enhancing regenerative processes in hepatic tissue (Cai et al., 2024).
- Silybin pharmacological research: The pharmacological effects of silybin, particularly its roles in inhibiting inflammation and modulating drug metabolizing enzymes, make it a valuable compound in therapeutic research, particularly for its benefits in hepatology and oncology (Hammad et al., 2024).
Analysis Note
Appearance of substance (visual): powder
Colour index (0,5 M in DMF): ≤ 150 Hazen
Identity (IR): passes test
Enantiomeric purity: ≥ 99.8 % (a/a)
Purity (HPLC): ≥ 99.0 % (a/a)
Fmoc-ß-Ala-OH (HPLC): ≤ 0.1 % (a/a)
Fmoc-ß-Ala-Asp (OtBu)-OH (HPLC): ≤ 0.1 % (a/a)
Fmoc-Asp(OtBu)-Asp(OtBu)-OH (HPLC): ≤ 0.1 % (a/a)
Fmoc-Asp-OH (HPLC): ≤ 0.1 % (a/a)
Assay free amino acid (GC): ≤ 0.2 %
Purity (TLC(011A)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Solubility (25 mmole in 50 ml DMF): clearly soluble
Assay (acidimetric): ≥ 98.0 %
Water (K. F.): ≤ 2.0 %
Ethyl acetate (HS-GC): ≤ 0.5 %
Acetate (IC): ≤ 0.02 %
To see the solvent systems used for TLC of Novabiochem® products please click here.
Other Notes
Legal Information
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Related Content
Introducing enhanced specifications for 20 standard Fmoc-amino acids, ensuring ≥99% HPLC purity and improved yields for high-quality peptide synthesis.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 8520050025 | 04027269084554 |
| 8520050100 | 04027269084561 |
| 8520050500 | 04027269179168 |
| 8520051000 | 04027269179175 |
| 8520050250 | 04027269206925 |