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G0355000

Glutamic acid

Name: Glutamic acid
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

L-Glutamic acid, (S)-2-Aminopentanedioic acid, Glu

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About This Item

Linear Formula:

HO₂CCH₂CH₂CH(NH₂)CO₂H

CAS Number:

56-86-0

Molecular Weight:

147.13

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329799811

MDL number:

MFCD00002634

Beilstein/REAXYS Number:

1723801

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Properties

grade

pharmaceutical primary standard

API family

glutamic acid

manufacturer/tradename

EDQM

mp

205 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

N[C@@H](CCC(O)=O)C(O)=O

InChI

1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1

InChI key

WHUUTDBJXJRKMK-VKHMYHEASA-N

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Glutamic acid EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

An excitatory amino acid neurotransmitter that is an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA).

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Mechanism underlying unaltered cortical inhibitory synaptic transmission in contrast with enhanced excitatory transmission in CaV2.1 knockin migraine mice.

Dania Vecchia et al.

Neurobiology of disease, 69, 225-234 (2014-06-08)

Familial hemiplegic migraine type 1 (FHM1), a monogenic subtype of migraine with aura, is caused by gain-of-function mutations in CaV2.1 (P/Q-type) calcium channels. In FHM1 knockin mice, excitatory neurotransmission at cortical pyramidal cell synapses is enhanced, but inhibitory neurotransmission at

Structural and molecular remodeling of dendritic spine substructures during long-term potentiation.

Miquel Bosch et al.

Neuron, 82(2), 444-459 (2014-04-20)

Synapses store information by long-lasting modifications of their structure and molecular composition, but the precise chronology of these changes has not been studied at single-synapse resolution in real time. Here we describe the spatiotemporal reorganization of postsynaptic substructures during long-term

Balance and stability of synaptic structures during synaptic plasticity.

Daniel Meyer et al.

Neuron, 82(2), 430-443 (2014-04-20)

Subsynaptic structures such as bouton, active zone, postsynaptic density (PSD) and dendritic spine, are highly correlated in their dimensions and also correlate with synapse strength. Why this is so and how such correlations are maintained during synaptic plasticity remains poorly

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Global Trade Item Number

SKU	GTIN
G0355000	04061833623558