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P3700000

Propylthiouracil

Name: Propylthiouracil
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

6-Propyl-2-thiouracil, 2,3-Dihydro-6-propyl-2-thioxo-4(1H)-pyrimidinone, 4-Hydroxy-2-mercapto-6-propylpyrimidine

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About This Item

Empirical Formula (Hill Notation):

C₇H₁₀N₂OS

CAS Number:

51-52-5

Molecular Weight:

170.23

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329820187

MDL number:

MFCD00006041

Beilstein/REAXYS Number:

130039

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Properties

grade

pharmaceutical primary standard

description

enzyme inhibitor

API family

propylthiouracil

manufacturer/tradename

EDQM

mp

218-220 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CCCC1=CC(=O)NC(=S)N1

InChI

1S/C7H10N2OS/c1-2-3-5-4-6(10)9-7(11)8-5/h4H,2-3H2,1H3,(H2,8,9,10,11)

InChI key

KNAHARQHSZJURB-UHFFFAOYSA-N

Gene Information

human ... DIO1(1733), TPO(7173)

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Propylthiouracil EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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pictograms

GHS08,GHS07

signalword

Warning

hcodes

H302,H351

pcodes

P201 - P301 + P312 + P330 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Propylthiouracil hepatitis: report of a case and extensive review of the literature.

Eleni Memi et al.

Journal of pediatric endocrinology & metabolism : JPEM, 25(3-4), 331-343 (2012-07-10)

Antithyroid drugs (ATDs) have been widely and effectively used for the treatment of pediatric and adult thyrotoxicosis for more than a half century. Since the very beginning of ATD use, reports of hepatic dysfunction related to propylthiouracil (PTU) therapy have

Pathogenesis of propylthiouracil-related hepatotoxicity in children: present concepts.

Spiros Karras et al.

Journal of pediatric endocrinology & metabolism : JPEM, 25(7-8), 623-630 (2012-11-20)

Propylthiouracil (PTU), carbimazole (CMZ) and methimazole (MMI) are the most common drugs used today in cases of adolescent thyrotoxicosis. Skepticism has been growing regarding the use of PTU in childhood and its association with severe liver failure. The aim of

Long-term propylthiouracil use and acute myeloid leukemia: a case report and review of the literature.

Daniele Focosi et al.

Annals of hematology, 87(3), 233-235 (2007-09-12)

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Global Trade Item Number

SKU	GTIN
P3700000	04061834372813