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PHR1197

Iminostilbene

Name: Iminostilbene
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

5H-Dibenz[b,f]azepine, Carbamazepine Related Compound B, Iminostilbene

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About This Item

Empirical Formula (Hill Notation):

C₁₄H₁₁N

CAS Number:

256-96-2

Molecular Weight:

193.24

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329823205

EC Number:

205-970-0

Beilstein/REAXYS Number:

1343358

MDL number:

MFCD00005071

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Properties

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to USP 1093023

API family

carbamazepine, oxcarbazepine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

N1c2ccccc2C=Cc3ccccc13

InChI

1S/C14H11N/c1-3-7-13-11(5-1)9-10-12-6-2-4-8-14(12)15-13/h1-10,15H

InChI key

LCGTWRLJTMHIQZ-UHFFFAOYSA-N

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards..

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAA9013 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

GHS07,GHS09

signalword

Warning

hcodes

H302,H411

pcodes

P273

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Effect of chemical structure on complexation efficiency of aromatic drugs with cyclodextrins: The example of dibenzazepine derivatives.

Hemine, et al.

Carbohydrate Polymers, 250, 116957-116957 (2021)

Production of specific antibodies and development of a non-isotopic immunoassay for carbamazepine by the carbonyl metallo-immunoassay (CMIA) method.

A Varenne et al.

Journal of immunological methods, 186(2), 195-204 (1995-10-26)

As part of our ongoing work to extend the range of applications of the non-isotopic carbonyl metalloimmunoassay (CMIA), previously developed in our laboratory, we describe here the first CMIA study of carbamazepine. The CMIA method uses a metal carbonyl complex

Carbamazepine metabolism to a reactive intermediate by the myeloperoxidase system of activated neutrophils.

S M Furst et al.

Biochemical pharmacology, 45(6), 1267-1275 (1993-03-24)

Carbamazepine is an anticonvulsant which is associated with a significant incidence of hypersensitivity reactions including agranulocytosis. We have postulated that many drug hypersensitivity reactions, especially agranulocytosis and lupus, are due to reactive metabolites generated by the myeloperoxidase (MPO) (EC 1.11.1.7)

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Global Trade Item Number

SKU	GTIN
PHR1197-500MG	04061835513154