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PHR1254

Acyclovir

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Acycloguanosine, 9-[(2-Hydroxyethoxy)methyl]guanine, Acyclovir

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About This Item

Empirical Formula (Hill Notation):
C8H11N5O3
CAS Number:
59277-89-3
Molecular Weight:
225.20
NACRES:
NA.24
PubChem Substance ID:
329823257
UNSPSC Code:
41116107
EC Number:
261-685-1
MDL number:
MFCD00057880
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Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. A0220000, traceable to USP 1012065

API family

acyclovir

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

NC1=Nc2c(ncn2COCCO)C(=O)N1

InChI

1S/C8H11N5O3/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14/h3,14H,1-2,4H2,(H3,9,11,12,15)

InChI key

MKUXAQIIEYXACX-UHFFFAOYSA-N

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Acyclovir is an acyclic guanosine derivative effective in the treatment of skin infections caused by herpes simplex virus.

Application

Acyclovir may be used as a pharmaceutical reference standard for the determination of the analyte in plasma, serum samples and bulk drug/formulations by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC2956 in the slot below. This is an example certificate only and may not be the lot that you receive.

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Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Simple spectrophotometric determination of acyclovir in bulk drug and formulations
Basavaiah K and Prameela HC
Il Farmaco (Societa Chimica Italiana : 1989), 57(6), 443-449 (2002)
Determination of acyclovir in human serum by high-performance liquid chromatography using liquid--liquid extraction and its application in pharmacokinetic studies
Bahrami Gh, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 816(1-2), 327-331 (2005)
Determination of acyclovir in human plasma by high-performance liquid chromatography
Boulieu R, et al
Journal of Chromatography. B, Biomedical Sciences and Applications, 693(1), 233-236 (1997)
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Global Trade Item Number

SKUGTIN
PHR1254-1G04061835233304