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PHR1638

Alfuzosin hydrochloride

Name: Alfuzosin hydrochloride
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

N-(3-((4-Amino-6,7-dimethoxy-2-quinazolinyl)methylamino)propyl)tetrahydro-2-furancarboxamide hydrochloride, Uroxatral hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₂₇N₅O₄ · HCl

CAS Number:

81403-68-1

Molecular Weight:

425.91

NACRES:

NA.24

PubChem Substance ID:

329823527

UNSPSC Code:

41116107

MDL number:

MFCD00879135

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Properties

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. A0325800, traceable to USP 1012917

API family

alfuzosin

CofA

current certificate can be downloaded

packaging

ampule of 1 × 1 g

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Cl.COc1cc2nc(nc(N)c2cc1OC)N(C)CCCNC(=O)C3CCCO3

InChI

1S/C19H27N5O4.ClH/c1-24(8-5-7-21-18(25)14-6-4-9-28-14)19-22-13-11-16(27-3)15(26-2)10-12(13)17(20)23-19;/h10-11,14H,4-9H2,1-3H3,(H,21,25)(H2,20,22,23);1H

InChI key

YTNKWDJILNVLGX-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Alfuzosin hydrochloride may be used as a pharmaceutical reference standard for the quantification of alfuzosin hydrochloride levels in pharmaceutical formulations by reverse phase high-performance liquid chromatography (RP-HPLC), high performance thin layer chromatography (HPTLC) and spectrophotometry.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Alfuzosin hydrochloride is an alpha-adrenergic blocker used to treat benign prostatic hyperplasia (BPH). It works by relaxing the muscles in the prostate and bladder neck, making it easier to urinate.

Alfuzosin hydrochloride is an alpha-adrenergic blocker.

Other Notes

To see an example of a Certificate of Analysis for this material enter LRAA5304 in the slot below. This is an example certificate only and may not be the lot that you receive.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Development of new spectrophotometric methods for the determination of Alfuzosin hydrochloride in bulk and pharmaceutical formulations

Kumar DR, et al.

Orient. J. Chem., 24(2), 725-728 (2008)

Validated HPLC and HPTLC stability-indicating methods for determination of alfuzosin hydrochloride in bulk powder and pharmaceutical formulations

Salah FA, et al.

Journal of Separation Science, 29(18), 2716-2724 (2006)

Development and validation of reverse phase high performance liquid chromatography and high performance thin layer chromatography methods for estimation of alfuzosin hydrochloride in bulk and in pharmaceutical formulations

Patel DB and Patel NJ

International Journal of ChemTech Research, 1(4), 985-990 (2009)

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Global Trade Item Number

SKU	GTIN
PHR1638-1G	04061834793236