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PHR1903

Citalopram Related Compound D

Name: Citalopram Related Compound D
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Citalopram Related Compound D, 1-(4-Fluorophenyl)-1-(3-methylaminopropyl)-1,3-dihydroisobenzofuran-5-carbonitrile hydrochloride, 1-(4-Fluorophenyl)-1-(3-methylamino)propyl)-1,3-dihydroisobenzofuran-5-carbonitrile hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₁₉FN₂O · HCl

Molecular Weight:

346.83

UNSPSC Code:

41116107

NACRES:

NA.24

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Properties

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to USP 1134277

API family

citalopram

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Fc1ccc(cc1)C2(OCc3c2ccc(c3)C#N)CCCNC.Br

InChI

1S/C19H19FN2O.BrH/c1-22-10-2-9-19(16-4-6-17(20)7-5-16)18-8-3-14(12-21)11-15(18)13-23-19;/h3-8,11,22H,2,9-10,13H2,1H3;1H

InChI key

DJCAYVHVPUEMQJ-UHFFFAOYSA-N

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Citalopram Related Compound D is a related impurity found in the drug citalopram. Citalopram is a racemic bicyclic phthalane derivative and is a potent anti-depressant drug, that acts by inhibition of serotonin uptake.

Application

Citalopram Related Compound D may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAB0345 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Development and optimization of an HPLC analysis of citalopram and its four nonchiral impurities using experimental design methodology

Tadi T, et al.

Journal of AOAC (Association of Official Analytical Chemists) International, 95(3), 733-743 (2012)

Semi-preparative isolation and structural elucidation of an impurity in citalopram by LC/MS/MS

Raman B, et al.

Journal of Pharmaceutical and Biomedical Analysis, 50(3), 377-383 (2009)

Global Trade Item Number

SKU	GTIN
PHR1903-30MG	04061835220717