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PHR2006

Allopurinol Related Compound B

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

3-(Formylamino)-1H-pyrazole-4-carboxamide, 5-(Formylamino)-1H-pyrazole-4-carboxamide

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About This Item

Empirical Formula (Hill Notation):
C5H6N4O2
CAS Number:
22407-20-1
Molecular Weight:
154.13
UNSPSC Code:
41116107
NACRES:
NA.24
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Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. A0350020, traceable to USP 1013013

API family

allopurinol

CofA

current certificate can be downloaded

packaging

pkg of 50 mg

application(s)

pharmaceutical

format

neat

storage temp.

2-8°C

SMILES string

[nH]1ncc(c1NC=O)C(=O)N

InChI

1S/C5H6N4O2/c6-4(11)3-1-8-9-5(3)7-2-10/h1-2H,(H2,6,11)(H2,7,8,9,10)

InChI key

MKVXRGIJTKYXPR-UHFFFAOYSA-N

General description

Allopurinol Related Compound B is an impurity of allopurinol. Allopurinol is a purine analog and a structural isomer of the naturally available purine in the body, hypoxanthine. It is also a powerful xanthine oxidase inhibitor. It is widely utilized against purine and pyrimidine metabolic disorders that give rise to an excess of uric acid in humans.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Allopurinol Related Compound B may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB7872 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Allopurinol
USP42-NF37: United States Pharmacopeia and National Formulary
United States Pharmacopeia/National Formulary, 34(1), 132-132 (2018)
High-performance liquid chromatography with polarographic and voltammetric anodic detection: simultaneous determination of allopurinol, oxipurinol and uric acid in body fluids
Palmisano F, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 306(1), 205-214 (1984)
Development of a stability indicating RP-RRLC method for determination of allopurinol and its degradation products in solid oral dosage
Singh S and Gadhawala Z
International Journal of PharmTech Research, 5(1), 44-53 (2013)

Global Trade Item Number

SKUGTIN
PHR2006-50MG04061835238422