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Y0000676

Gemcitabine impurity A

Name: Gemcitabine impurity A
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Cytosine, 4-Amino-2-hydroxypyrimidine, 4-Aminopyrimidin-2-(1H)-one

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About This Item

Empirical Formula (Hill Notation):

C₄H₅N₃O

CAS Number:

71-30-7

Molecular Weight:

111.10

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329831090

MDL number:

MFCD00006034

Beilstein/REAXYS Number:

2637

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Properties

grade

pharmaceutical primary standard

API family

gemcitabine

manufacturer/tradename

EDQM

mp

>300 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

NC1=NC(=O)NC=C1

InChI

1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)

InChI key

OPTASPLRGRRNAP-UHFFFAOYSA-N

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Gemcitabine impurity A EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Base-resolution maps of 5-methylcytosine and 5-hydroxymethylcytosine in Dahl S rats: effect of salt and genomic sequence.

Yong Liu et al.

Hypertension (Dallas, Tex. : 1979), 63(4), 827-838 (2014-01-15)

Analysis of 5-hydroxymethylcytosine (5hmC) at single-base resolution has been largely limited to studies of stem cells or developmental stages. Given the potential importance of epigenetic events in hypertension, we have analyzed 5hmC and 5-methylcytosine (5mC) at single-base resolution in the

Cytosine methylation and DNA repair.

C P Walsh et al.

Current topics in microbiology and immunology, 301, 283-315 (2006-03-31)

Cytosine methylation is a common form of post-replicative DNA modification seen in both bacteria and eukaryotes. Modified cytosines have long been known to act as hotspots for mutations due to the high rate of spontaneous deamination of this base to

TET proteins: on the frenetic hunt for new cytosine modifications.

Benjamin Delatte et al.

Briefings in functional genomics, 12(3), 191-204 (2013-04-30)

Epigenetic genome marking and chromatin regulation are central to establishing tissue-specific gene expression programs, and hence to several biological processes. Until recently, the only known epigenetic mark on DNA in mammals was 5-methylcytosine, established and propagated by DNA methyltransferases and

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Global Trade Item Number

SKU	GTIN
Y0000676	04061837577659