Skip to Content
Merck
CN

Key Documents

View All Documentation

D6140

Demeclocycline hydrochloride

powder or crystals, suitable for cell culture

Synonym(s):

7-Chloro-6-demethyltetracycline hydrochloride, Demethylchlorotetracycline hydrochloride

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):
C21H21ClN2O8 · HCl
CAS Number:
64-73-3
Molecular Weight:
501.31
NACRES:
NA.75
PubChem Substance ID:
24278380
UNSPSC Code:
12352207
EC Number:
200-592-2
MDL number:
MFCD00082371
Beilstein/REAXYS Number:
3849198
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

Demeclocycline hydrochloride, powder or crystals

assay

89.5-102.0% anhydrous basis

Quality Level

200

form

powder or crystals

technique(s)

cell culture | mammalian: suitable

solubility

soluble (1 mg/mL of Demeclocycline Hydrochloride in 0.01 N hydrochloric acid)

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

protein synthesis | interferes

storage temp.

−20°C

SMILES string

Cl[H].[H][C@]12C[C@@]3([H])[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C(=O)c4c(O)ccc(Cl)c4[C@H]2O

InChI

1S/C21H21ClN2O8.ClH/c1-24(2)14-7-5-6-10(16(27)12-9(25)4-3-8(22)11(12)15(6)26)18(29)21(7,32)19(30)13(17(14)28)20(23)31;/h3-4,6-7,14-15,25-26,28-29,32H,5H2,1-2H3,(H2,23,31);1H/t6-,7-,14-,15-,21-;/m0./s1

InChI key

GVSJQNRGSCOSNJ-KBHRXELFSA-N

General description

Chemical structure: tetracycline

Biochem/physiol Actions

Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.
Demeclocycline hydrochloride is a tetracycline antibiotic derived from a strain of Streptomyces aureofaciens. DMC protects neurons from glutamate induced toxicity by suppressing calpain I and II activities.
Used to study mechanisms of bacterial protein synthesis inhibition at the level of the 30S subunit and aminoacy-tRNA A-site binding.

Still not finding the right product?

Explore all of our products under Demeclocycline hydrochloride

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Muta. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Information

涉药品监管产品

This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
108M4884V
028M4786V
076M4755V
BCBQ0861V
BCBM0381V

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

B Athanassiadis et al.
Australian dental journal, 55(2), 150-155 (2010-07-08)
The in vitro antimicrobial activity of a series of endodontic medicaments and their bases against biofilms of Enterococcus faecalis was investigated. The medicaments tested were Pulpdent paste, Ledermix paste, a 50:50 Ledermix and Pulpdent mixture, and a replica of Ledermix
P Lenherr et al.
International endodontic journal, 45(10), 942-949 (2012-04-18)
To investigate the discoloration potential of endodontic materials using a bovine tooth model. Two hundred and 10 dentine-enamel cuboid blocks (10 × 10 × 3.5 mm) were prepared out of the middle thirds of bovine tooth crowns. Standardized cavities were
Quan V Ho et al.
Journal of endodontics, 36(1), 119-122 (2009-12-17)
Traditional culture-based techniques for assessing infection of the root canal system are difficult to use and prone to error. Real-time assessment of the microbial status of the root canal system using laser fluorescence would help address these limitations. This study
View All Related Papers

Global Trade Item Number

SKUGTIN
D6140-1G04061833587317