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D9305

1-Deoxynojirimycin hydrochloride

Name: 1-Deoxynojirimycin hydrochloride
Brand: SIGMA

Synonym(s):

1,5-Dideoxy-1,5-imino-D-sorbitol hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₆H₁₃NO₄ · HCl

CAS Number:

73285-50-4

Molecular Weight:

199.63

UNSPSC Code:

12352201

NACRES:

NA.32

PubChem Substance ID:

24278397

MDL number:

MFCD00133247

Beilstein/REAXYS Number:

3563225

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Properties

assay

≥98% (TLC)

Quality Level

200

form

powder

solubility

water: 19.60-20.40 mg/mL, clear, colorless

antibiotic activity spectrum

viruses

mode of action

enzyme | inhibits

storage temp.

2-8°C

SMILES string

Cl[H].OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C6H13NO4.ClH/c8-2-3-5(10)6(11)4(9)1-7-3;/h3-11H,1-2H2;1H/t3-,4+,5-,6-;/m1./s1

InChI key

ZJIHMALTJRDNQI-VFQQELCFSA-N

Gene Information

human ... GAA(2548)

Description

General description

Chemical structure: glucosamine

Application

1-Deoxynojirimycin hydrochloride has been used

to study its effects on the loss-of-function of N-glycosylation pathway on hair cell regeneration
as an endoplasmic reticulum (ER) α-glucosidase I and II inhibitor to study its effects on TMED3-cystic fibrosis transmembrane conductance regulator (CFTR) interaction
as an insect trehalase inhibitor in TREH inhibition bioassay

Biochem/physiol Actions

α-Glucosidase inhibitor

1-Deoxynojirimycin (DNJ) is a naturally occurring alkaloid azasugar or iminosugar. It is observed in mulberry leaves, Commelina communis, and bacterial strains including Bacillus and Streptomyces species. DNJ acts as an α-glucosidase inhibitor and exhibits anti-viral anti-diabetic, anti-inflammatory, anti-obesity, and antioxidant properties.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Disease and patient characteristics in NP-C patients: findings from an international disease registry.

Marc C Patterson et al.

Orphanet journal of rare diseases, 8, 12-12 (2013-01-18)

Niemann-Pick disease type C (NP-C) is a rare neurovisceral disease characterized by progressive neurodegeneration and premature death. We report data recorded at enrolment in an ongoing international NP-C registry initiated in September 2009 to describe disease natural history, clinical course

Miglustat as a therapeutic agent: prospects and caveats.

Rosemarie E Venier et al.

Journal of medical genetics, 49(9), 591-597 (2012-08-16)

A viable treatment for lysosomal storage disease has been very difficult to attain. One option is pharmacological inhibition of synthetic pathways to reduce substrate accumulations. Miglustat N-butyldeoxynojirimycin (NBDNJ), an inhibitor of glucosylceramide synthase, has shown much promise in clinical trials

Evaluation of miglustat as maintenance therapy after enzyme therapy in adults with stable type 1 Gaucher disease: a prospective, open-label non-inferiority study.

Timothy M Cox et al.

Orphanet journal of rare diseases, 7, 102-102 (2012-12-29)

Previous studies have provided equivocal data on the use of miglustat as maintenance therapy in Gaucher disease type 1. We report findings from a clinical trial evaluating the effects of miglustat treatment in patients with stable type 1 Gaucher disease

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Global Trade Item Number

SKU	GTIN
D9305-10MG	04061833590607
D9305-5MG	04061833590614