I3265
Interferon-γ human
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), lyophilized powder, suitable for cell culture
Synonym(s):
IFN-γ
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About This Item
biological source
human
Quality Level
recombinant
expressed in E. coli
assay
≥98% (SDS-PAGE)
form
lyophilized powder
mol wt
~17 kDa
packaging
pkg of 0.1 mg
technique(s)
cell culture | mammalian: suitable
impurities
≤1 EU/μg endotoxin
color
white
solubility
water: soluble 1.000 mL, clear, colorless
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... IFNG(3458)
Application
Interferon-γ human has been used:
- to study the effect of interferon-γ on cultured trophoblasts in absence and presence of fibronectin
- to analyse factors which participate in the production of antibody microarrays on glass support
- for ELISA (enzyme-linked immunosorbent assay) method to understand the effect of interferon-γ in human gingival fibroblasts in presence of bacterial challenge
Biochem/physiol Actions
IFNG (interferon-γ) is a type-2 interferon which is produced by Th (T helper cells)-1 lymphocytes, CD8 cytotoxic lymphocytes, natural killer (NK) cells, and natural killer T (NKT) cells. It plays an important role in innate and adaptive immune responses, and helps in defense against bacterial infections, dimorphic yeast and some viral infections. High expression of IFNG is common in many autoimmune diseases, such as systemic lupus erythematosis, Sjögren syndrome, inflammatory bowel disease and multiple sclerosis.
Physical form
Lyophilized from phosphate buffered saline.
Analysis Note
The biological activity is measured by a viral resistance assay.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Related Content
K Pfizenmaier et al.
Cancer research, 45(8), 3503-3509 (1985-08-01)
The effect of recombinant gamma-interferon (IFN-gamma) on established human colon carcinoma cell lines as well as fresh tumor cells from colon carcinoma patients has been investigated with respect to growth inhibition, enhancement of HLA expression, and modulation of immunogenicity. A
R Pijnenborg et al.
Molecular human reproduction, 6(7), 635-641 (2000-06-29)
Tumour necrosis factor (TNF)-alpha and interferon (IFN)-gamma, produced by maternal inflammatory cells, may compromise trophoblast survival at the trophoblast-maternal interface and notably in the placental bed which is invaded by trophoblast. Extracellular matrix components, e.g. fibronectin, may enhance trophoblast survival.
Marielle Kaplan et al.
Inflammation, 41(4), 1477-1487 (2018-04-25)
Arterial macrophages comprise a heterogeneous population: pro-inflammatory (M1) and anti-inflammatory (M2). Since C-reactive protein (CRP) is produced by macrophages in atherosclerotic lesions, understanding of CRP regulation in macrophages could be crucial to decipher inflammatory patterns in atherogenesis. We aimed to
Global Trade Item Number
| SKU | GTIN |
|---|---|
| I3265-.1MG | 04061833848968 |