I5521
Monoclonal Anti-Interferon-γ antibody produced in mouse
clone 25718, purified immunoglobulin, lyophilized powder
Synonym(s):
Anti-IFN-γ
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About This Item
Conjugate:
unconjugated
Clone:
25718, monoclonal
Application:
ICC, Neutral
Citations:
6
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
25718, monoclonal
form
lyophilized powder
species reactivity
human
technique(s)
immunocytochemistry: 8-25 μg/mL using immersion fixed human peripheral blood mononuclear cells stimulated with PMA and ionomycin, neutralization: suitable
impurities
endotoxin, tested
isotype
IgG2a
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... IFNG(3458)
Immunogen
recombinant human interferon-γ, expressed and purified from Escherichia coli.
Biochem/physiol Actions
Interferons (IFNs) are cytokines that are secreted in response to viral or bacterial infections and tumorigenesis. IFN-γ binds to specific receptor complex consisting of IFNγR1 and IFNγR2. There are many pathways that are mediated by IFN-γ binding such as JAK/STAT1, AP-1, NF-κB, STAT3 and STAT5. IFN-γ is pleotropic and performs various functions related to immune response, inflammation, differentiation and activation of T cells, cell cycle and apoptosis.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 5% trehalose.
Preparation Note
Purified using protein A affinity chromatography.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
低风险生物材料
常规特殊物品
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Related Content
Meager, A. et al.
Lymphokines and Interferons, A Practical Approach, 129-129 (1987)
Wlad Kusnezow et al.
Proteomics, 3(3), 254-264 (2003-03-11)
Antibody microarrays could have an enormous impact on the functional analysis of cellular activity and regulation, especially at the level of protein expression and protein-protein interaction, and might become an invaluable tool in disease diagnostics. The array surface is bound
M Raza Zaidi et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 17(19), 6118-6124 (2011-06-28)
Interferon-γ is a cytokine whose biological activity is conventionally associated with cytostatic/cytotoxic and antitumor mechanisms during cell-mediated adaptive immune response. It has been used clinically to treat a variety of malignancies, albeit with mixed results and side effects that can
Global Trade Item Number
| SKU | GTIN |
|---|---|
| I5521-.5MG | 04061832714585 |