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Merck
CN

I6891

H-7

Synonym(s):

1-(5-Isoquinolinesulfonyl)-2-methylpiperazine, Isoquinoline-5-sulfonic 2-methyl-1-piperazide

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About This Item

Empirical Formula (Hill Notation):
C14H17N3O2S
CAS Number:
Molecular Weight:
291.37
UNSPSC Code:
12352200
NACRES:
NA.77
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
5482740
Assay:
≥98% (HPLC)
Form:
powder
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assay

≥98% (HPLC)

form

powder

mp

114 °C

solubility

ethanol: 20 mg/mL, 1 M HCl: 5 mg/mL

storage temp.

2-8°C

SMILES string

CC1CNCCN1S(=O)(=O)c2cccc3cnccc23

InChI

1S/C14H17N3O2S/c1-11-9-16-7-8-17(11)20(18,19)14-4-2-3-12-10-15-6-5-13(12)14/h2-6,10-11,16H,7-9H2,1H3

InChI key

BDVFVCGFMNCYPV-UHFFFAOYSA-N

Gene Information

human ... CALCRL(10203)
rat ... Calcrl(25029)

Biochem/physiol Actions

Inhibitor of cyclic nucleotide dependent protein kinase (PKA) and protein kinase C.


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

新产品

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Chunyun Liu et al.
PloS one, 8(2), e54841-e54841 (2013-02-19)
We observed the therapeutic effect of Fasudil and explored its mechanisms in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Fasudil, a selective Rho kinase (ROCK) inhibitor, was injected intraperitoneally at 40 mg/kg/d in early and late
Alice Bayiyana et al.
Journal of fungi (Basel, Switzerland), 5(3) (2019-07-20)
Despite improvement in the prognosis of HIV/AIDS (human immunodeficiency virus/acquired immune deficiency syndrome) patients on antiretroviral therapy (ART), cryptococcal meningitis (CM) still causes 10-15% mortality among HIV-infected patients. The immunological impact of ART on the CD4+ and CD8+ T cell
Torben Gehring et al.
Cell reports, 29(4), 873-888 (2019-10-24)
The CARMA1/CARD11-BCL10-MALT1 (CBM) complex bridges T and B cell antigen receptor (TCR/BCR) ligation to MALT1 protease activation and canonical nuclear factor κB (NF-κB) signaling. Using unbiased mass spectrometry, we discover multiple serine phosphorylation sites in the MALT1 C terminus after



Global Trade Item Number

SKUGTIN
I6891-25MG04061832434049
I6891-5MG04061832434056