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L7757

Lidocaine

Name: Lidocaine
Brand: SIGMA

≥98% (GC), powder, neuroprotective agent

Synonym(s):

2-Diethylamino-N-(2,6-dimethylphenyl)acetamide, Lignocaine, Xylocaine

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About This Item

Empirical Formula (Hill Notation):

C₁₄H₂₂N₂O

CAS Number:

137-58-6

Molecular Weight:

234.34

NACRES:

NA.77

PubChem Substance ID:

24896480

UNSPSC Code:

12352200

EC Number:

205-302-8

MDL number:

MFCD00026733

Form:

powder

Quality level:

100

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Properties

Product Name

Lidocaine, powder

form

powder

Quality Level

100

SMILES string

CCN(CC)CC(=O)Nc1c(C)cccc1C

InChI

1S/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17)

InChI key

NNJVILVZKWQKPM-UHFFFAOYSA-N

Gene Information

human ... CYP1A2(1544), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)
rat ... Scnn1a(25122)

Description

General description

Lidocaine is a local anesthetic and an effective antiarrhythmia agent. It occurs as solutions of crystalline colorless solid for injections, that has a short half-life within plasma.

Application

Lidocaine may be used for drug testing and for voltage clamp experiments.

Biochem/physiol Actions

Lidocaine, a neuroprotective agent, mediates blockage of sodium (Na⁺) channels. It prevents the influx of sodium ions leading to depolarization of sodium channels and metabolically inactivated in liver. Lidocaine has positive effect on cerebral ischemia. It is also used in the treatment of ventricular tachycardia. Lidocaine is an efficient anesthetic agent in ophthalmic surgeries as it is highly potent and has good tissue penetrability.

Na⁺ channel blocker; class IB antiarrhythmic that is rapidly absorbed after parenteral administration.

Na⁺ channel blocker; class IB antiarrhythmic.

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pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Information

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Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy (2008)

Cytotoxicity of lidocaine to human corneal endothelial cells in vitro

Yu HZ, et al.

Basic and Clinical Pharmacology and Toxicology, 114(4), 352-359 (2014)

A microfluidic gradient maker for toxicity testing of bupivacaine and lidocaine

Tirella A, et al.

Toxicology in vitro, 22(8), 1957-1964 (2008)

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Global Trade Item Number

SKU	GTIN
L7757-25G	04061835374779
L7757-100G	04061833965665