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M1544

Resorufin methyl ether

Name: Resorufin methyl ether
Brand: SIGMA

Synonym(s):

7-Methoxy-3H-phenoxazin-3-one, Methoxyresorufin, O⁷-Methylresorufin

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About This Item

Empirical Formula (Hill Notation):

C₁₃H₉NO₃

CAS Number:

5725-89-3

Molecular Weight:

227.22

UNSPSC Code:

12161501

NACRES:

NA.47

PubChem Substance ID:

24896665

MDL number:

MFCD00037663

Beilstein/REAXYS Number:

209529

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Properties

assay

≥98.0% (HPLC)

Quality Level

200

form

powder

mp

≥220 °C (lit.)

solubility

dichloromethane: 0.95-1.05 mg/mL, clear, orange to very deep orange

storage temp.

2-8°C

SMILES string

COc1ccc2N=C3C=CC(=O)C=C3Oc2c1

InChI

1S/C13H9NO3/c1-16-9-3-5-11-13(7-9)17-12-6-8(15)2-4-10(12)14-11/h2-7H,1H3

InChI key

KNYYMGDYROYBRE-UHFFFAOYSA-N

Description

Application

Resorufin methyl ether have been used as substrate in the incubation mixture, during the determination of cytochrome P4501A activities such as ethoxyresorufin O-deethylase (EROD) and methoxyresorufin O-demethylase(MROD) in liver microsomes, using high performance liquid chromatography(HPLC).

Biochem/physiol Actions

Fluorimetric substrate for cytochrome P450 linked enzymes.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Articles

一期药物代谢

一期生物转化反应在药物上引入或暴露官能团，目的是增加化合物的极性。尽管一期药物代谢发生在大多数组织中，但代谢的主要和首过部位发生在肝循环期间。

Phase I Drug Metabolism

Phase I biotransformation reactions increase drug compound polarity, mainly occurring in hepatic circulation.

Dissecting the insecticide-resistance- associated cytochrome P450 gene Cyp6g1.

McCart C and ffrench-Constant R H

Pest Management Science, 64(6), 639-645 (2008)

Determination of cytochrome P450 1A activities in mammalian liver microsomes by high-performance liquid chromatography with fluorescence detection

Hanioka N, et al.

Journal of Chromatography. B, Biomedical Sciences and Applications, 744(2), 399-406 (2000)

Arginine to lysine 108 substitution in recombinant CYP1A2 abolishes methoxyresorufin metabolism in lymphoblastoid cells.

Nicholas E Hadjokas et al.

British journal of pharmacology, 136(3), 347-352 (2002-05-25)

1. Cytochrome P4501A2 (CYP1A2) activates a large number of procarcinogens to carcinogens. Phytochemicals such as flavones can inhibit CYP1A2 activity competitively, and hydroxylated derivatives of flavone (galangin) may be potent, selective inhibitors of CYP1A2 activity relative to CYP1A1 activity. Molecular

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Global Trade Item Number

SKU	GTIN
M1544-1MG	04061834040859
M1544-5MG	04061834040866