M9656
H-8 dihydrochloride
>98% (HPLC)
Synonym(s):
N-[2-(Methylamino)ethyl]-5-isoquinolinesulfonamide hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C12H15N3O2S · 2HCl
CAS Number:
Molecular Weight:
338.25
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
>98% (HPLC)
Form:
powder
assay
>98% (HPLC)
form
powder
storage temp.
2-8°C
SMILES string
Cl[H].Cl[H].CNCCNS(=O)(=O)c1cccc2cnccc12
InChI
1S/C12H15N3O2S.2ClH/c1-13-7-8-15-18(16,17)12-4-2-3-10-9-14-6-5-11(10)12;;/h2-6,9,13,15H,7-8H2,1H3;2*1H
InChI key
RJJLZYZEVNCZIW-UHFFFAOYSA-N
Gene Information
human ... CALCRL(10203), PRKAR1A(5573), PRKAR1AP(5574), PRKAR1B(5575), PRKAR2A(5576), PRKAR2B(5577)
rat ... Calcrl(25029)
Biochem/physiol Actions
cAMP and cGMP-dependent protein kinase inhibitor.
Features and Benefits
This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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F Shirakawa et al.
Molecular and cellular biology, 9(6), 2424-2430 (1989-06-01)
We have examined whether a precursor form of NF-kappa B, a DNA-binding protein that plays a role in the transcriptional control of several genes, including kappa immunoglobulin light chain and interleukin-2 receptor alpha subunit, could be activated in vitro by
H Hidaka et al.
Biochemistry, 23(21), 5036-5041 (1984-10-09)
Naphthalenesulfonamides such as N-(6-amino-hexyl)-5-chloro-1-naphthalenesulfonamide (W-7) are potent calmodulin (CaM) antagonists and act upon several protein kinases at higher concentration. When the naphthalene ring was replaced by isoquinoline, the derivatives were no longer CaM antagonists but retained the ability to inhibit
Global Trade Item Number
| SKU | GTIN |
|---|---|
| M9656-5MG | 04061832449012 |