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MAK071

Pyruvate Assay Kit

sufficient for 100 colorimetric or fluorometric tests

Synonym(s):

Assay Kit for Pyruvate Detection

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About This Item

NACRES:
NA.84
UNSPSC Code:
12161503
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usage

sufficient for 100 colorimetric or fluorometric tests

detection method

colorimetric, fluorometric

relevant disease(s)

gastrointestinal diseases; cancer

storage temp.

−20°C

Gene Information

human ... PKLR(5313), PKM2(5315)
mouse ... PKLR(18770), PKM2(18746)
rat ... PKLR(24651), PKM2(25630)

General description

Pyruvate is a central molecule in metabolism that is used and synthesized through multiple metabolic pathways including glycolysis and the transamination of alanine. Pyruvate may be further oxidized in the citric acid cycle, converted to carbohydrates during gluconeogenesis, or reduced to lactate. High levels of pyruvate are associated with liver disease and genetic disorders. Pyruvate has also been used to stimulate metabolism leading to loss of body weight.

Application

Suitable for measuring pyruvate concentration in various biological samples such as blood, tissues, and culture cells.

Biochem/physiol Actions

Pyruvate concentration is determined by a coupled enzyme assay, which results in a colorimetric (570 nm)/fluorometric (λex = 535/λem = 587 nm) product, proportional to the pyruvate present.

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pictograms

Health hazard
GHS08

signalword

Danger

Storage Class

10 - Combustible liquids

wgk

WGK 3

Hazard Classifications

Aquatic Chronic 3 - ED ENV 1 - Resp. Sens. 1 - Skin Sens. 1

Regulatory Information

常规特殊物品

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Certificates of Analysis (COA)

Lot/Batch Number
7L22K06090
7F07K06090
7A04K06090
6F05K06090
6B18K06090

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Articles

需氧糖酵解和瓦博格效应

本页面介绍了一篇有关瓦博格效应的文章，以及其如何能够在正常氧气水平下，增强肿瘤细胞中葡萄糖向乳酸的转化。Otto Heinrich Warburg在1924年证明，癌细胞显示出对糖酵解的依赖性增加，以满足他们的能量需求，无论是否有充足的氧气存在。

Aerobic Glycolysis and the Warburg Effect

Warburg effect enhances glucose to lactate conversion in tumor cells, regardless of oxygen levels; impacting cancer metabolism since 1924.

Changes in muscle cell metabolism and mechanotransduction are associated with myopathic phenotype in a mouse model of collagen VI deficiency.
De Palma S, et al.
PLoS ONE, 8(2), e56716-e56716 (2013)
Abstracts of the XVIth International Conference on Biological Inorganic Chemistry, July 22-26, 2013, Grenoble, France.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 19 Suppl 1, 1-696 (2014-03-13)
Zhudong Liu et al.
Journal of agricultural and food chemistry, 68(49), 14660-14669 (2020-12-02)
Spinosyns, the secondary metabolites produced by Saccharopolyspora spinosa, are the active ingredients in a family of novel biological insecticides. Although the complete genome sequence of S. spinosa has been published, the transcriptome of S. spinosa remains poorly characterized. In this
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Global Trade Item Number

SKUGTIN
MAK071-1KT04061835516674