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P7762

Poly-L-arginine hydrochloride

Name: Poly-<SC>L</SC>-arginine hydrochloride
Brand: SIGMA

mol wt 15,000-70,000

Synonym(s):

L-Arginine homopolymer hydrochloride

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About This Item

CAS Number:

26982-20-7

NACRES:

NA.26

PubChem Substance ID:

24898874

UNSPSC Code:

12352209

MDL number:

MFCD00166393

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Properties

form

powder

Quality Level

200

mol wt

15,000-70,000

color

white to off-white

application(s)

cell analysis

storage temp.

−20°C

SMILES string

Cl.NC(CCCNC(N)=N)C(O)=O

InChI

1S/C18H38N12O4.ClH/c19-10(4-1-7-26-16(20)21)13(31)29-11(5-2-8-27-17(22)23)14(32)30-12(15(33)34)6-3-9-28-18(24)25;/h10-12H,1-9,19H2,(H,29,31)(H,30,32)(H,33,34)(H4,20,21,26)(H4,22,23,27)(H4,24,25,28);1H/t10-,11-,12-;/m0./s1

InChI key

PQEISBBDIRAKGR-LFELFHSZSA-N

Description

General description

Poly-L-arginine hydrochloride (PLA) is a homopolyamino acid. PLA enhances membrane permeability compared to poly-L-lysine. It has applications as drug carrier, neuroprotective agent and in anticancer vaccines preparations. Peptide vaccines in conjugation with PLA promotes antigen-presenting cells (APCs) to generate T cell and elicit immunostimulant functionality.

Application

Poly-L-arginine hydrochloride has been used:

to generate complex with stimulatory RNA isRNA9.2 as in neutrophils
used in ribosomal RNA transfection into human monocytic THP-1 cells
for coating alginate capsule beads

Analysis Note

Contains 3% or less ornithine residue.

Molecular weight based on viscosity of precursor poly-L-ornithine. Also assayed by MALLS.

Other Notes

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Articles

Layer-by-Layer (LbL) Assembly, A "Gentle Yet Flexible" Method Toward Functional Biomaterials

Recently, layer-by-layer (LbL) assembly has emerged as a versatile, gentle and, simple method for immobilization of functional molecules in an easily controllable thin film morphology.1,2 In this short review, we introduce recent advances in functional systems fabricated by using the mild, yet adaptable LbL technique.

Poly(Amino Acid) Block Copolymers for Drug Delivery and other Biomedical Applications

Humankind has utilized protein materials throughout its existence, starting with the use of materials such as wool and silk for warmth and protection from the elements and continuing with the use of recombinant DNA techniques to synthesize proteins with unique and useful properties.

Factors influencing the mechanical stability of alginate beads applicable for immunoisolation of mammalian cells

Bhujbal SV, et al.

Journal of the Mechanical Behavior of Biomedical Materials, 37, 196-208 (2014)

Vaccination with poly-L-arginine as immunostimulant for peptide vaccines: induction of potent and long-lasting T-cell responses against cancer antigens

Mattner F, et al.

Cancer Research, 62(5), 1477-1480 (2002)

Neutrophils express distinct RNA receptors in a non-canonical way

Berger M, et al.

The Journal of Biological Chemistry, 287(23), 19409-19417 (2012)

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Global Trade Item Number

SKU	GTIN
P7762-10MG	04061832780498
P7762-100MG	04061834397366
P7762-50MG	04061832780504