P8296
5-Phospho-D-ribose 1-diphosphate pentasodium salt
≥75% (HPLC)
Synonym(s):
α-D-Ribosyl diphosphate 5-phosphate pentasodium salt, 5-Phospho-α-D-ribosyl diphosphate, 5-Phosphoribosyl 1-pyrophosphate pentasodium salt, P-Rib-PP, PRPP pentasodium salt
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About This Item
Empirical Formula (Hill Notation):
C5H8Na5O14P3
CAS Number:
Molecular Weight:
499.98
UNSPSC Code:
12352201
NACRES:
NA.25
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
6043637
Quality Level
assay
≥75% (HPLC)
form
powder
impurities
<18% water (Karl Fischer)
color
white
solubility
water: 50 mg/mL, clear to slightly hazy, colorless to very faintly yellow
shipped in
dry ice
storage temp.
−20°C
SMILES string
[Na+].[Na+].[Na+].[Na+].O[C@H]1[C@@H](O)[C@H](O[C@@H]1COP(O)([O-])=O)OP([O-])(=O)OP([O-])([O-])=O
InChI
1S/C5H13O14P3.4Na/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13;;;;/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13);;;;/q;4*+1/p-4/t2-,3-,4-,5?;;;;/m1..../s1
InChI key
QZAPPJHVNYCTAX-CKJQBBATSA-J
General description
Substrate for phosphoribosyltransferases in the synthesis of nucleotides.
Application
Pentasodium salt has been used in a study to assess the relationship between the muscarinic receptor cationic current and internal calcium in guinea-pig jejunal smooth muscle cells. It has also been used in a study to investigate inhibitors of the bacterial cell wall biosynthesis of the enzyme Mur D.
Analysis Note
Purity ≥ 75% based on an assay system using orotidine-5′-phosphate pyrophosphorylase and orotidine-5′-phosphate decarboxylase mixed enzymes.
Other Notes
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P Pacaud et al.
The Journal of physiology, 441, 477-499 (1991-09-01)
1. The action of carbachol, which activates muscarinic receptors, was studied in single patch-clamped cells where free internal calcium concentration in the cell (Cai2+) was estimated using the emission from the dye Indo-1. Cells were dialysed with potassium-free caesium solution
L D Gegnas et al.
Bioorganic & medicinal chemistry letters, 8(13), 1643-1648 (1999-01-05)
A series of transition-state analog inhibitors of the D-glutamic acid-adding enzyme (MurD) of bacterial peptidoglycan biosynthesis has been synthesized and evaluated for inhibition of the E. coli enzyme.
Matthew Bratkowski et al.
Cell reports, 32(5), 107999-107999 (2020-08-07)
The NADase SARM1 is a central switch in injury-activated axon degeneration, an early hallmark of many neurological diseases. Here, we present cryo-electron microscopy (cryo-EM) structures of autoinhibited (3.3 Å) and active SARM1 (6.8 Å) and provide mechanistic insight into the tight regulation
Global Trade Item Number
| SKU | GTIN |
|---|---|
| P8296-250MG | 04061832392677 |
| P8296-100MG | 04061834401278 |
| P8296-25MG | 04061834401285 |
| P8296-500MG | 04061834401292 |