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S1141

Spermine tetrahydrochloride

BioReagent, Molecular Biology

Synonym(s):

N,N′-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride

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About This Item

Empirical Formula (Hill Notation):
C10H26N4 · 4HCl
CAS Number:
306-67-2
Molecular Weight:
348.18
UNSPSC Code:
12352116
NACRES:
NA.52
PubChem Substance ID:
24899462
EC Number:
206-189-8
Beilstein/REAXYS Number:
3911771
MDL number:
MFCD00012914
Form:
solid
Quality level:
300
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grade

Molecular Biology

Quality Level

300

product line

BioReagent

form

solid

mp

310-311 °C (dec.) (lit.)

solubility

H2O: soluble 100 mg/mL, clear, colorless to light yellow

foreign activity

DNase, RNase, protease, NICKase, none detected

storage temp.

room temp

SMILES string

Cl.Cl.Cl.Cl.NCCCNCCCCNCCCN

InChI

1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H

InChI key

XLDKUDAXZWHPFH-UHFFFAOYSA-N

General description

Spermine is a polyamine involved in cellular metabolism and DNA stabilization. In molecular biology it can be used in buffers for purification of DNA.

Application

Used to precipitate DNA from low salt aqueous buffers.

Biochem/physiol Actions

Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Mixed NMDA agonist/antagonist at the polyamine site. Role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

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pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCG9744
BCCG6714
BCCF5684
BCCF5352
BCCC8318

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Protocols

Spermine Tetrahydrochloride for Molecular Biology

This product is suitable for DNA precipitation from low salt aqueous buffers. It has been tested for the absence of proteases and nucleases.

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Product Information Sheet - S1141
D M Hougaard et al.
The Biochemical journal, 238(1), 43-47 (1986-08-15)
Two recently developed fluorescence cytochemical methods, specific for spermidine and spermine, were used to localize polyamines in the endocrine pancreas. The polyamines were restricted to the insulin-producing beta-cells and were mainly associated with the secretory granules. Chemical polyamine determinations carried
Binh V Vu et al.
PloS one, 7(12), e51863-e51863 (2013-01-04)
While most nucleic acids are intracellular, trace amounts of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), including micro RNAs, can also be found in peripheral blood. Many studies have suggested the potential utility of these circulating nucleic acids in prenatal
Aracely A Lutes et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(24), 9910-9915 (2011-05-06)
Speciation in animals commonly involves an extrinsic barrier to genetic exchange followed by the accumulation of sufficient genetic variation to impede subsequent productive interbreeding. All-female species of whiptail lizards, which originated by interspecific hybridization between sexual progenitors, are an exception
View All Related Papers

Global Trade Item Number

SKUGTIN
SAB1309036-400UL04065272322645
S1141-10G04061833613283
S1141-1G04061836908836
S1141-5G04061836908867