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A1752

Adenosine 5′-monophosphate sodium salt

Name: Adenosine 5&#8242;-monophosphate sodium salt
Brand: SIGMA

≥99%, from yeast, powder

Synonym(s):

5′-Adenylic acid, A-5′-P, AMP

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₄N₅O₇P · xNa⁺ · yH₂O

CAS Number:

149022-20-8

Molecular Weight:

347.22 (anhydrous free acid basis)

MDL number:

MFCD08689634

UNSPSC Code:

41106305

eCl@ss:

32160414

PubChem Substance ID:

24890583

NACRES:

NA.51

Assay:

≥99%

Biological source:

yeast

Form:

powder

Solubility:

H₂O: soluble

Storage temp.:

−20°C

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Properties

Product Name

Adenosine 5′-monophosphate sodium salt, from yeast, ≥99%

biological source

yeast

Quality Level

300

assay

≥99%

form

powder

solubility

H₂O: soluble

storage temp.

−20°C

SMILES string

NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@]((COP(O)(O)=O)([H])O3.C.

Description

Application

Adenosine 5′-monophosphate sodium salt has been used:

as a component of reactivation medium to reactivate mouse sperm extracted from caudae epididymides for sperm motility studies
as a substrate in signal amplification by reversible exchange (SABRE) method to develop biocompatible SABRE hyperpolarization
as a substrate in wheat and Aspergillus niger phytase, assay
in luciferase assay to monitor intracellular α-synuclein oligomerization in S1S2 cells
to study its effects on induction of therapeutic hypothermia and neuronal damage in a rat model of cardiac arrest (CA) and resuscitation

Biochem/physiol Actions

Adenosine 5′-monophosphate (5′-AMP) is used to enhance flavor in meat and poultry soups. It is also used as a food additive for specific nutritional purposes. 5′-AMP is an activator of a class of protein kinases known as AMP-activated protein kinase (AMPK). Along with inosine monophosphate (IMP), AMP mediates the dissociation of skeletal muscle actomyosin to actin and myosin. Therefore, these two factors may be involved in causing the resolution of rigor mortis in muscles.

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Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Protocols

5'-核苷酸酶的酶促检测

在测定5′-核苷酸酶活性时，本操作流程使用5′-单磷酸腺苷和一种显色试剂生成的标准曲线而对释放的磷的微摩尔数进行测定。

LC/MS Analysis of Nucleotides on SeQuant ZIC-cHILIC

HILIC separation is an alternative that permits sensitive MS detection and without the use of ion-pair reagents.

Enzymatic Assay of 5’-Nucleotidase

To measure 5′-nucleotidase activity, this procedure uses adenosine 5’-monophosphate and a color reagent to create a standard curve for determining the micromoles of phosphorus liberated.

5'-AMP-activated protein kinase is inactivated by adrenergic signalling in adult cardiac myocytes.

Yugo Tsuchiya et al.

Bioscience reports, 32(2), 197-213 (2011-08-20)

In adult rat cardiac myocytes adrenaline decreased AMPK (AMP-activated protein kinase) activity with a half-time of approximately 4 min, decreased phosphorylation of AMPK (α-Thr172) and decreased phosphorylation of ACC (acetyl-CoA carboxylase). Inactivation of AMPK by adrenaline was through both α1- and

Simultaneous 15 N polarization of several biocompatible substrates in ethanol-water mixtures by signal amplification by reversible exchange (SABRE) method.

Alexey S Kiryutin et al.

Magnetic resonance in chemistry : MRC (2021-06-05)

Signal amplification by reversible exchange (SABRE) is a popular method for generating strong signal enhancements in nuclear magnetic resonance (NMR). In SABRE experiments, the source of polarization is provided by the nonthermal spin order of parahydrogen (pH2 , the H2

Sustained compensatory p38 MAPK signaling following treatment with MAPK inhibitors induces the immunosuppressive protein CD73 in cancer: combined targeting could improve outcomes.

Mikkel G Terp et al.

Molecular oncology, 15(12), 3299-3316 (2021-06-25)

RAS-MAPK signaling promotes immune evasion and cancer cell survival, and MAPK inhibitors (MAPKis) are frequently used as cancer therapies. Despite progress elucidating the direct effects of MAPKi on immune cells, their indirect effect on the tumor microenvironment (TME) through changes

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Global Trade Item Number

SKU	GTIN
A1752-1G	04061833342930
A1752-100MG	04061831168426
A1752-25G	04061833342947
A1752-5G	04061833342954