Lithium L-lactate

Lithium L-lactate, also known as Sarcolactic acid lithium or Lithium (S)-2-hydroxypropanoate, is a lithium salt of L-lactic acid, the optically active isomer of lactic acid characterized by an (S) stereochemical arrangement. L-Lactic acid is naturally produced in animals through the fermentation of pyruvate via lactate dehydrogenase during normal metabolism and exercise. This compound is a crucial element in lactic acid fermentation carried out by lactic acid bacteria, where carbohydrates are converted into lactic acid. In humans, lactic acid and its conjugate base play vital roles in various biological processes, spanning from prenatal development to the maintenance of the extracellular fluid surrounding neurons.

Recent research indicates that Lithium L-lactate exhibits mood-stabilizing effects, particularly in individuals with bipolar disorder. This impact is believed to be linked to its influence on the phosphatidylinositol (PI) pathway and the inhibition of glycogen synthase kinase-3 (GSK-3) activity. Beyond bipolar disorder, ongoing investigations are exploring the potential applications of Lithium L-lactate in neuropsychiatric conditions, including studies related to depression, anxiety, and schizophrenia, highlighting its significance in the areas of metabolomics and biochemical research.

Lithium L-lactate has been used as a standard:

• for the quantification of lactic acid using analytical methods
• for the quantification of lactic acid using high-performance liquid chromatography
• as a standard for L-lactic acid assay

Lithium L-lactate is a versatile compound that finds application in metabolomics and biochemical research.

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