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Merck
CN

112208

4-硝基苯甲酰氯

98%

别名:

p-Nitrobenzoyl chloride

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关于此项目

线性分子式:
O2NC6H4COCl
化学文摘社编号:
分子量:
185.56
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
204-517-4
Beilstein/REAXYS Number:
473192
MDL number:
Assay:
98%
Form:
solid
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Quality Level

assay

98%

form

solid

bp

202-205 °C/105 mmHg (lit.)

mp

71-74 °C (lit.)

functional group

acyl chloride, nitro

SMILES string

[O-][N+](=O)c1ccc(cc1)C(Cl)=O

InChI

1S/C7H4ClNO3/c8-7(10)5-1-3-6(4-2-5)9(11)12/h1-4H

InChI key

SKDHHIUENRGTHK-UHFFFAOYSA-N

General description

对硝基苯甲酰氯与三苯基膦盐反应,通过分子内维蒂希反应合成苯并呋喃(潜在正电子发射断层扫描 (PET) 示踪剂)。它已被用于二醇(雄烯二醇,前列腺癌的内源性增殖剂)的衍生化

Application

<ul>
<li><strong>[11C]PiB的自动合成::</strong> 4-硝基苯甲酰氯被用于[11C]PiB的自动合成,[11C]PiB是一种用于淀粉样蛋白PET成像的放射性药物,研究突出了其在增强神经成像技术方面的作用 (Singh et al., 2024)。</li>
</ul>


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pictograms

Corrosion

signalword

Danger

hcodes

Hazard Classifications

Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1B

存储类别

8A - Combustible corrosive hazardous materials

wgk

WGK 1

flash_point_f

215.6 °F - closed cup

flash_point_c

102 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

危险化学品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Masahiro Ono et al.
Journal of medicinal chemistry, 49(9), 2725-2730 (2006-04-28)
A novel series of benzofuran derivatives as potential positron emission tomography (PET) tracers targeting amyloid plaques in Alzheimer's disease (AD) were synthesized and evaluated. The syntheses of benzofurans were successfully achieved by an intramolecular Wittig reaction between triphenylphosphonium salt and
Tatsuya Higashi et al.
Steroids, 71(11-12), 1007-1013 (2006-09-19)
Androstenediol (Adiol, androst-5-ene-3beta,17beta-diol) is suspected of being an endogenous proliferation agent of prostate cancer (PCa) even after androgen deprivation therapy (ADT). A liquid chromatography-electron capture atmospheric pressure chemical ionization-mass spectrometric (LC-ECAPCI-MS) method for the determination of Adiol in prostatic tissue
M Ishigai et al.
Analytical biochemistry, 298(1), 83-92 (2001-10-25)
The dynamics of enzyme-catalyzed glutathione conjugation was studied by electrospray quadrupole/time-of-flight (Q-TOF) mass spectrometry with a nanospray interface. After incubation of human glutathione S-transferase A1-1 (GT) with glutathione (GSH) and an electrophilic substrate, electrospray indicated the presence of enzyme/product adducts



全球贸易项目编号

货号GTIN
112208-500G04061832489117
112208-250G04061835281329
112208-50G04061835281336