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Merck
CN

11373

HATU

≥98.0% (CHN), for peptide synthesis

别名:

1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate, N-[(Dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide

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关于此项目

经验公式(希尔记法):
C10H15F6N6OP
化学文摘社编号:
分子量:
380.23
UNSPSC Code:
12352302
PubChem Substance ID:
NACRES:
NA.22
MDL number:
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产品名称

HATU, ≥98.0% (CHN)

Quality Level

assay

≥98.0% (CHN)

form

solid

reaction suitability

reaction type: Coupling Reactions

mp

183-185 °C (lit.), 183-188 °C (dec.)

application(s)

peptide synthesis

functional group

amine

storage temp.

2-8°C

SMILES string

F[P-](F)(F)(F)(F)F.CN(C)[C+](N(C)C)n1n[n+]([O-])c2ncccc12

InChI

1S/C10H15N6O.F6P/c1-13(2)10(14(3)4)15-8-6-5-7-11-9(8)16(17)12-15;1-7(2,3,4,5)6/h5-7H,1-4H3;/q+1;-1

InChI key

FKBFHOSFPRWJNV-UHFFFAOYSA-N

Application

Reagent for:
Synthesis of Aurora A kinase inhibitors
HPLC assay to determine D- and L- acid enantiomers in human plasma
Amide bond formation reactions

Catalyst for:
Selective acylation
Selecocyclization-oxidation deselenation sequence

Other Notes

Recent studies show that crystal as well as solution structure of this coupling agent is a guanidinium N-oxide and not an uronium compound; Advantageous coupling reagent for solid-phase peptide synthesis.


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pictograms

Health hazard

signalword

Danger

hcodes

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1A

supp_hazards

存储类别

4.1A - Other explosive hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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The uronium/guanidinium Peptide coupling reagents: finally the true uronium salts.
Louis A Carpino et al.
Angewandte Chemie (International ed. in English), 41(3), 441-445 (2002-12-20)
L. Carpino et al.
Journal of the Chemical Society. Chemical Communications, 201-201 (1994)
Mazen Jamous et al.
Nuclear medicine and biology, 41(6), 464-470 (2014-05-02)
The gastrin-releasing peptide receptor (GRPR) was shown to be expressed with high density on several types of cancers. Radiolabeled peptides for imaging and targeted radionuclide therapy have been developed. In this study, we evaluated the potential of statine-based bombesin antagonists



全球贸易项目编号

货号GTIN
379816-1G04061831951530
205796-10G04061838768162
205796-2G04061838768179
11373-5G04061833354926
11373-1G04061838701411
11373-25G04061833416440