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123129

2-氨基噻唑

Name: 2-氨基噻唑
Brand: ALDRICH

97%

别名:

2-噻唑胺

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关于此项目

经验公式（希尔记法）:

C₃H₄N₂S

化学文摘社编号:

96-50-4

分子量:

100.14

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24847523

EC Number:

202-511-6

Beilstein/REAXYS Number:

105738

MDL number:

MFCD00005325

Assay:

97%

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属性

Quality Level

100

assay

97%

mp

91-93 °C (lit.)

solubility

1 M HCl: soluble 50 mg/mL, clear (dark yellow-brown)

SMILES string

Nc1nccs1

InChI

1S/C3H4N2S/c4-3-5-1-2-6-3/h1-2H,(H2,4,5)

InChI key

RAIPHJJURHTUIC-UHFFFAOYSA-N

说明

Application

2-氨基噻唑用于合成 2-氨基噻唑修饰硅胶。在超声辐射介导下与 2-氯苯甲酸进行 Ulmann 偶联。

Biochem/physiol Actions

2-氨基噻唑是有效的细胞周期蛋白依赖性激酶 5 抑制剂，是治疗阿尔茨海默病和其他神经退行性疾病的治疗药物。

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pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Design and synthesis of 7-alkoxy-4-heteroarylamino-3-quinolinecarbonitriles as dual inhibitors of c-Src kinase and nitric oxide synthase.

Xin Cao et al.

Bioorganic & medicinal chemistry, 16(11), 5890-5898 (2008-05-20)

Because both c-Src and iNOS are key regulatory enzymes in tumorigenesis, a new series of 4-heteroarylamino-3-quinolinecarbonitriles as potent dual inhibitors of both enzymes were designed, prepared, and evaluated for blocking multiple signaling pathways in cancer therapy. All compounds were evaluated

Synthetic Communications, 37, 1853-1853 (2007)

Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer's disease.

Christopher J Helal et al.

Bioorganic & medicinal chemistry letters, 14(22), 5521-5525 (2004-10-16)

High-throughput screening with cyclin-dependent kinase 5 (cdk5)/p25 led to the discovery of N-(5-isopropyl-thiazol-2-yl)isobutyramide (1). This compound is an equipotent inhibitor of cdk5 and cyclin-dependent kinase 2 (cdk2)/cyclin E (IC(50)=ca. 320nM). Parallel and directed synthesis techniques were utilized to explore the

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全球贸易项目编号

货号	GTIN
123129-100G	04061838722089
123129-5G	04061838722102
123129-500G	04061838722096