Quality Level
assay
97%
form
solid
bp
208 °C/25 mmHg (lit.)
mp
55-57 °C (lit.)
functional group
ketone, phenyl
SMILES string
[H]\C(=C(\[H])C(=O)c1ccccc1)c2ccccc2
InChI
1S/C15H12O/c16-15(14-9-5-2-6-10-14)12-11-13-7-3-1-4-8-13/h1-12H/b12-11+
InChI key
DQFBYFPFKXHELB-VAWYXSNFSA-N
Gene Information
human ... IL1B(3553)
rat ... Ar(24208)
General description
反式 -查尔酮是一种开链类黄酮，可能预防肺癌和前胃癌。
Application
反式-查尔酮用于合成cis和反式二苯基环丙烷。 它还用于筛选异丁基苯和 4-异丁基苯乙酮的表面吸附物质，用于散装的 Fsfotungstic Wells-Dawson 酸 (H6P2W18O62.xH2O)。
Biochem/physiol Actions
反式-查耳酮具有抗红霉素的抗真菌活性。它是脂肪酸合成酶和α-淀粉酶的抑制剂。由于拟南芥根中线粒体跨膜电位降低，它可诱导程序性细胞死亡。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Sylvie Ducki et al.
Bioorganic & medicinal chemistry, 17(22), 7698-7710 (2009-10-20)
The alpha-methyl chalcone SD400 is a potent inhibitor of tubulin assembly and possesses potent anticancer activity. Various chalcone analogues were synthesized and evaluated for their cell growth inhibitory properties against the K562 human chronic myelogenous leukemia cell line (SD400, IC(50)
Wattenberg L.W., et al.
Cancer Letters, 15, 165-165 (1994)
Daniela Batovska et al.
European journal of medicinal chemistry, 44(5), 2211-2218 (2008-07-01)
A large series of chalcones were synthesized and studied against Staphylococcus aureus and Escherichia coli. Chalcones were either unsubstituted in ring A or possessed 4'-chloro or 3',4',5'-trimethoxy groups. Their other ring B was variously substituted. It was found that the
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 136123-100G | 04061838731142 |
| 136123-5G | 04061838731159 |