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Merck
CN

142859

二氟乙酸

98%

别名:

1,1-Difluoroacetic acid, 2,2-Difluoroacetic acid

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关于此项目

线性分子式:
F2CHCO2H
化学文摘社编号:
分子量:
96.03
UNSPSC Code:
12352106
NACRES:
NA.22
PubChem Substance ID:
EC Number:
206-839-0
Beilstein/REAXYS Number:
1098588
MDL number:
Assay:
98%
Form:
liquid
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Quality Level

assay

98%

form

liquid

refractive index

n20/D 1.344 (lit.)

bp

132-134 °C (lit.)

mp

−1 °C (lit.)

density

1.526 g/mL at 25 °C (lit.)

functional group

carboxylic acid, fluoro

SMILES string

OC(=O)C(F)F

InChI

1S/C2H2F2O2/c3-1(4)2(5)6/h1H,(H,5,6)

InChI key

PBWZKZYHONABLN-UHFFFAOYSA-N

General description

二氟乙酸是一种单羧酸,也是一种有机氟化合物。二氟乙酸是一种易于操作的试剂,用于制备二氟甲基取代基。二氟乙酸可用作直接对杂环化合物进行C−H二氟甲基化的二氟甲基化试剂。

Application

用于在三苯基膦的介导下,由邻位取代苯胺制备 2-二氟化甲基苯并咪唑、-噁唑和-噻唑。


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pictograms

CorrosionExclamation mark

signalword

Danger

Hazard Classifications

Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1A

存储类别

8A - Combustible corrosive hazardous materials

wgk

WGK 3

flash_point_f

172.4 °F - closed cup

flash_point_c

78 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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N Illy et al.
Comptes rendus des seances de la Societe de biologie et de ses filiales, 175(2), 242-246 (1981-01-01)
Our experiments were carried out in normal and streptozotocin-diabetic rats. The effects of sodium difluoroacetate (DFA) at the dose of 40 mg/kg daily were studied on the blood and retinal lactate levels; these effects were compared to those of an
J N Commandeur et al.
Biochemical pharmacology, 37(23), 4495-4504 (1988-12-01)
The biotransformation and the hepato- and nephrotoxicity of the mercapturic acids (N-acetyl-1-cysteine S-conjugates) of three structurally related 2,2-difluoroethylenes were investigated in vivo in the rat. All mercapturic acids appeared to cause nephrotoxicity, without any measureable effect on the liver. The
Ute Dorgerloh et al.
Molecules (Basel, Switzerland), 24(6) (2019-03-17)
The concentrations of difluoroacetic acid (DFA) and trifluoroacetic acid (TFA) in rainwater and surface water from Berlin, Germany resembled those reported for similar urban areas, and the TFA/DFA ratio in rainwater of 10:1 was in accordance with the literature. In



全球贸易项目编号

货号GTIN
142859-25G04061838118004
142859-5G04061838734501