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144487

2-氨基-3-苄氧基吡啶

Name: 2-氨基-3-苄氧基吡啶
Brand: ALDRICH

99%

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关于此项目

经验公式（希尔记法）:

C₁₂H₁₂N₂O

化学文摘社编号:

24016-03-3

分子量:

200.24

NACRES:

NA.22

PubChem Substance ID:

24848659

UNSPSC Code:

12352100

EC Number:

245-983-9

MDL number:

MFCD00006316

Assay:

99%

Form:

solid

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属性

Quality Level

100

assay

99%

form

solid

mp

92-94 °C (lit.)

functional group

phenyl

SMILES string

Nc1ncccc1OCc2ccccc2

InChI

1S/C12H12N2O/c13-12-11(7-4-8-14-12)15-9-10-5-2-1-3-6-10/h1-8H,9H2,(H2,13,14)

InChI key

NMCBWICNRJLKKM-UHFFFAOYSA-N

Gene Information

human ... MAPK14(1432)

说明

General description

2-Amino-3-benzyloxypyridine on condensation with diethyl ethoxymethylene malonate affords 9-benzyloxy-3-ethoxycarbonylpyrido[1,2-a]pyrimidin-4-one.

Application

2-Amino-3-benzyloxypyridine was used in the synthesis of 1-acetyl-2-[2-(3-benzyloxypyridinyl)]iminoimidazolidine.

Biochem/physiol Actions

2-Amino-3-benzyloxypyridine is an inhibitor of mitogen-activated protein kinase p38α activity.

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Synthesis of new heterocyclic phenols: 9-Hydroxypyrido [1, 2-a] pyrimidin-4-one and Derivatives.

Dennin F, et al.

Journal of Heterocyclic Chemistry, 28(5), 1287-1291 (1991)

Synthesis and evaluation of new pyridyl/pyrazinyl thiourea derivatives: Neuroprotection against amyloid-β-induced toxicity.

Jung-Eun Park et al.

European journal of medicinal chemistry, 141, 322-334 (2017-10-17)

Herein, we report synthesis and evaluation of new twenty six small molecules against β amyloid (Aβ)-induced opening of mitochondrial permeability transition pore (mPTP) using JC-1 assay which measures the change of mitochondrial membrane potential (ΔΨm). The neuroprotective effect of seventeen

Discovery of 1-(3-(benzyloxy)pyridin-2-yl)-3-(2-(piperazin-1-yl)ethyl)urea: A new modulator for amyloid beta-induced mitochondrial dysfunction.

Ahmed Elkamhawy et al.

European journal of medicinal chemistry, 128, 56-69 (2017-02-06)

Herein, we report a new series of aliphatic substituted pyridyl-urea small molecules synthesized as potential modulators for amyloid beta (Aβ) induced mitochondrial dysfunction. Their blocking activities against Aβ-induced mitochondrial permeability transition pore (mPTP) opening were evaluated by JC-1 assay which

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全球贸易项目编号

货号	GTIN
144487-25G	04061832540986
144487-5G	04061832540993