Quality Level
assay
97%
form
solid
mp
176-178 °C (lit.)
functional group
amide, chloro
SMILES string
CC(=O)Nc1ccc(Cl)cc1
InChI
1S/C8H8ClNO/c1-6(11)10-8-4-2-7(9)3-5-8/h2-5H,1H3,(H,10,11)
InChI key
GGUOCFNAWIODMF-UHFFFAOYSA-N
General description
4'-氯乙酰苯胺是对乙酰氨基酚中存在的主要杂质,已经通过使用混合模式反相/阳离子交换固定相的新型高效液相色谱法定量。
Application
<ul>
<li><strong>高效液相色谱(HPLC)方法验证:</strong>4-氯乙酰胺被用作硝酸异山梨酯的内部标准品,通过高效液相色谱(HPLC)测定含有硝酸甘油、单硝酸异山梨酯或季戊四醇四硝酸酯的缓释片剂或胶囊中(Gelber and Papas, 1983)。</li>
</ul>
<li><strong>高效液相色谱(HPLC)方法验证:</strong>4-氯乙酰胺被用作硝酸异山梨酯的内部标准品,通过高效液相色谱(HPLC)测定含有硝酸甘油、单硝酸异山梨酯或季戊四醇四硝酸酯的缓释片剂或胶囊中(Gelber and Papas, 1983)。</li>
</ul>
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signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Tamas A Godany et al.
Chimia, 65(4), 253-255 (2011-06-18)
Lithiation of N-(4-chlorophenyl)-pivalamide (NCP) and two additional substituted acetanilides: 4-fluoroacetanilide (4-F) and 4-chloroacetanilide (4-Cl) has been monitored by means of calorimetry, on-line ATR-IR and UV/vis spectroscopy and endoscopy. The combined on-line monitoring revealed the differences between the reaction paths of
L Koymans et al.
Xenobiotica; the fate of foreign compounds in biological systems, 23(6), 633-648 (1993-06-01)
1. The general mechanism of metabolic oxidation of substrates by cytochromes P450 (P450s) appears to consist of sequential one-electron oxidation steps rather than of a single concerted transfer of activated oxygen species from P450 to substrates. 2. In case of
Octavian Călinescu et al.
Journal of chromatographic science, 50(4), 335-342 (2012-03-13)
Determination of acetaminophen and its main impurities: 4-nitrophenol, 4'-chloroacetanilide, as well as 4-aminophenol and its degradation products, p-benzoquinone and hydroquinone has been developed and validated by a new high-performance liquid chromatography method. Chromatographic separation has been obtained on a Hypersil
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 158631-25G | 04061835158133 |
| 158631-5G | 04061835158140 |
