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Merck
CN

158631

4′-氯乙酰苯胺

97%

别名:

4-氯乙酰苯胺, N-(4-氯苯基)乙酰胺, NSC 40563, NSC 444

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关于此项目

线性分子式:
CH3CONHC6H4Cl
化学文摘社编号:
分子量:
169.61
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
208-707-8
Beilstein/REAXYS Number:
509638
MDL number:
Assay:
97%
Form:
solid
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Quality Level

assay

97%

form

solid

mp

176-178 °C (lit.)

functional group

amide, chloro

SMILES string

CC(=O)Nc1ccc(Cl)cc1

InChI

1S/C8H8ClNO/c1-6(11)10-8-4-2-7(9)3-5-8/h2-5H,1H3,(H,10,11)

InChI key

GGUOCFNAWIODMF-UHFFFAOYSA-N

General description

4'-氯乙酰苯胺是对乙酰氨基酚中存在的主要杂质,已经通过使用混合模式反相/阳离子交换固定相的新型高效液相色谱法定量。

Application

<ul>
<li><strong>高效液相色谱(HPLC)方法验证:</strong>4-氯乙酰胺被用作硝酸异山梨酯的内部标准品,通过高效液相色谱(HPLC)测定含有硝酸甘油、单硝酸异山梨酯或季戊四醇四硝酸酯的缓释片剂或胶囊中(Gelber and Papas, 1983)。</li>
</ul>


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pictograms

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signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves



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分析证书(COA)

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Tamas A Godany et al.
Chimia, 65(4), 253-255 (2011-06-18)
Lithiation of N-(4-chlorophenyl)-pivalamide (NCP) and two additional substituted acetanilides: 4-fluoroacetanilide (4-F) and 4-chloroacetanilide (4-Cl) has been monitored by means of calorimetry, on-line ATR-IR and UV/vis spectroscopy and endoscopy. The combined on-line monitoring revealed the differences between the reaction paths of
L Koymans et al.
Xenobiotica; the fate of foreign compounds in biological systems, 23(6), 633-648 (1993-06-01)
1. The general mechanism of metabolic oxidation of substrates by cytochromes P450 (P450s) appears to consist of sequential one-electron oxidation steps rather than of a single concerted transfer of activated oxygen species from P450 to substrates. 2. In case of
Octavian Călinescu et al.
Journal of chromatographic science, 50(4), 335-342 (2012-03-13)
Determination of acetaminophen and its main impurities: 4-nitrophenol, 4'-chloroacetanilide, as well as 4-aminophenol and its degradation products, p-benzoquinone and hydroquinone has been developed and validated by a new high-performance liquid chromatography method. Chromatographic separation has been obtained on a Hypersil



全球贸易项目编号

货号GTIN
158631-25G04061835158133
158631-5G04061835158140