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164739

(+)-S-三苯甲基-L-半胱氨酸

Name: (+)-<I>S</I>-三苯甲基-<SC>L</SC>-半胱氨酸
Brand: ALDRICH

97%, for peptide synthesis

别名:

S-三苯甲基-L-半胱氨酸

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关于此项目

线性分子式:

(C₆H₅)₃CSCH₂CH(NH₂)CO₂H

化学文摘社编号:

2799-07-7

分子量:

363.47

UNSPSC Code:

12352209

eCl@ss:

32160406

PubChem Substance ID:

24850097

NACRES:

NA.22

Beilstein/REAXYS Number:

2339626

MDL number:

MFCD00002611

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属性

产品名称

(+)-S-三苯甲基-L-半胱氨酸, 97%

Quality Level

100

assay

97%

optical activity

[α]25/D +115°, c = 0.8 in 0.04 M ethanolic HCl

reaction suitability

reaction type: solution phase peptide synthesis

mp

182-183 °C (dec.) (lit.)

application(s)

peptide synthesis

SMILES string

N[C@@H](CSC(c1ccccc1)(c2ccccc2)c3ccccc3)C(O)=O

InChI

1S/C22H21NO2S/c23-20(21(24)25)16-26-22(17-10-4-1-5-11-17,18-12-6-2-7-13-18)19-14-8-3-9-15-19/h1-15,20H,16,23H2,(H,24,25)/t20-/m0/s1

InChI key

DLMYFMLKORXJPO-FQEVSTJZSA-N

说明

Application

(+)-S-三苯甲基 -L-半胱氨酸是一种非天然的含硫氨基酸，通常用作液相多肽合成（SPPS）中的溶剂。它还可用作金属结合剂，用于以 HBTU 肽偶联剂通过肽-金属相互作用合成可用于阳离子传感应用解决方案的取代的二茂铁酰肽偶联物。

pictograms

GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Molecular dissection of the inhibitor binding pocket of mitotic kinesin Eg5 reveals mutants that confer resistance to antimitotic agents.

Sébastien Brier et al.

Journal of molecular biology, 360(2), 360-376 (2006-06-20)

The mitotic kinesin Eg5 plays an essential role in establishing the bipolar spindle. Recently, several antimitotic inhibitors have been shown to share a common binding region on Eg5. Considering the importance of Eg5 as a potential drug target for cancer

Optimized S-trityl-L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models.

James A D Good et al.

Journal of medicinal chemistry, 56(5), 1878-1893 (2013-02-12)

The mitotic kinesin Eg5 is critical for the assembly of the mitotic spindle and is a promising chemotherapy target. Previously, we identified S-trityl-L-cysteine as a selective inhibitor of Eg5 and developed triphenylbutanamine analogues with improved potency, favorable drug-like properties, but

Proteome analysis of apoptosis signaling by S-trityl-L-cysteine, a potent reversible inhibitor of human mitotic kinesin Eg5.

Frank Kozielski et al.

Proteomics, 8(2), 289-300 (2008-01-11)

Mitotic kinesins represent potential drug targets for anticancer chemotherapy. Inhibitors of different chemical classes have been identified that target human Eg5, a kinesin responsible for the establishment of the bipolar spindle. One potent Eg5 inhibitor is S-trityl-L-cysteine (STLC), which arrests

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