199303
刃天青 钠盐
certified by the BSC
别名:
7-羟基-3H-吩恶嗪-3-酮-10-氧化物 钠盐
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关于此项目
经验公式（希尔记法）:
C12H6NNaO4
化学文摘社编号:
分子量:
251.17
UNSPSC Code:
12171500
NACRES:
NA.47
PubChem Substance ID:
EC Number:
263-718-5
Beilstein/REAXYS Number:
3794971
MDL number:
agency
certified by the BSC
Quality Level
form
powder
composition
Dye content, 75%
solubility
1 M NH4OH: 1 mg/mL
λmax
380 nm (2nd), 598 nm
application(s)
diagnostic assay manufacturing
hematology
histology
storage temp.
room temp
SMILES string
[Na+].[O-]c1ccc2c(OC3=CC(=O)C=CC3=[N+]2[O-])c1
InChI
1S/C12H7NO4.Na/c14-7-1-3-9-11(5-7)17-12-6-8(15)2-4-10(12)13(9)16;/h1-6,14H;/q;+1/p-1
InChI key
IVGPGQSSDLDOLH-UHFFFAOYSA-M
General description
刃天青(Resazurin)是二羟基吩噁嗪酮的N-氧化小分子衍生物。它是一种非离子染料，含有小的平面发色团。它是一种氧化还原指示剂，反应时由蓝紫色变为粉红色再变为无色。它也可用作3.5-6.5范围的pH指示剂，颜色由橙色变为蓝紫色。它的商品化形式为刃天青钠盐，也称3H-吩恶嗪-3-酮, 7-羟基-, 10-氧化物钠盐。经还原作用形成红色荧光的试卤灵（羟基吩噁嗪酮），进一步还原形成无色的氢化试卤灵。
Application
刃天青最常用作生物氧化还原指示剂。染料的生物还原减少了其氧化形式（蓝色）的含量，同时增加了荧光中间体（红色）水平。其应用包括：
- 测定酶活力和活细胞的增殖
- 检测乳汁中的细菌还原作用
- 在活力测定中用作检测活细菌的培养基成分
- 测定绵羊精液中活动精子的数目
- 检测乳酸脱氢酶
- 作为定量测定L-谷氨酸盐的分析试剂
用于测量活细胞的代谢活性和增殖。染料的生物还原减少了其氧化形式（蓝色）的含量，同时增加了荧光中间体（红色）水平。
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signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Morris E Feldman et al.
PLoS biology, 7(2), e38-e38 (2009-02-13)
The mammalian target of rapamycin (mTOR) regulates cell growth and survival by integrating nutrient and hormonal signals. These signaling functions are distributed between at least two distinct mTOR protein complexes: mTORC1 and mTORC2. mTORC1 is sensitive to the selective inhibitor
Andrej Wagner et al.
International journal of molecular sciences, 15(11), 20134-20157 (2014-11-08)
Photodynamic therapy (PDT) is a palliative treatment option for unresectable hilar biliary tract cancer (BTC) showing a considerable benefit for survival and quality of life with few side effects. Currently, factors determining the cellular response of BTC cells towards PDT
Hélène Chassin et al.
Nature communications, 10(1), 2013-2013 (2019-05-03)
Tight control over protein degradation is a fundamental requirement for cells to respond rapidly to various stimuli and adapt to a fluctuating environment. Here we develop a versatile, easy-to-handle library of destabilizing tags (degrons) for the precise regulation of protein
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 199303-25G | 04061835570386 |
| 199303-1G | 04061838763112 |
| 199303-5G | 04061835570393 |