240931
糖精
≥99%
别名:
2,3-二羟基-1,2-苯并异噻唑基-3-酮-1,1-二氧化物, 2-磺基苯甲酸亚胺, 邻磺酰苯酰亚胺
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关于此项目
经验公式（希尔记法）:
C7H5NO3S
化学文摘社编号:
分子量:
183.18
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
201-321-0
Beilstein/REAXYS Number:
6888
MDL number:
Assay:
≥99%
Form:
powder
Quality Level
assay
≥99%
form
powder
mp
226-229 °C (lit.)
solubility
acetone: 1g in 12mL(lit.), alcohol: 1g in 31mL(lit.), boiling water: 1g in 25mL(lit.), water: 1g in 25mL(lit.)
SMILES string
O=C1NS(=O)(=O)c2ccccc12
InChI
1S/C7H5NO3S/c9-7-5-3-1-2-4-6(5)12(10,11)8-7/h1-4H,(H,8,9)
InChI key
CVHZOJJKTDOEJC-UHFFFAOYSA-N
General description
人们研究了人工甜味剂——糖精（2-磺基苯甲酰亚胺）的生物降解。人们还研究了它的致癌潜力。
Application
- 具有增强的理化性质和体内吸收的加巴喷丁-糖精共晶，配制成口崩片：这项研究介绍了加巴喷丁-糖精共晶的制剂，证明了其溶解度和吸收的改善，这有利于药物应用（Soliman等人，2020年，doi：10.1080/10837450.2019.1687521）。
- 通过与糖精共非晶态制备来提高伊布替尼的溶解度、溶出度和生物利用度：该研究重点是通过与糖精的共非晶态制备来提高伊布替尼的生物利用度，这对于癌症治疗具有重要意义（Shi等人，2019，doi：10.1016/J.xphs.2019.04.031）。
Biochem/physiol Actions
哺乳动物的甜促味剂。有人提出，果蝇具有葡萄糖特异性甘油味觉受体结合位点。
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存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
N H Tran et al.
Bioresource technology, 161, 40-46 (2014-04-01)
The biodegradation of the six artificial sweetening agents including acesulfame (ACE), aspartame (ASP), cyclamate (CYC), neohesperidindihydrochalcone (NHDC), saccharin (SAC), and sucralose (SUC) by nitrifying activated sludge was first examined. Experimental results showed that ASP and NHDC were the most easily
Hugh P Morgan et al.
The Biochemical journal, 448(1), 67-72 (2012-08-22)
PYK (pyruvate kinase) plays a central role in the metabolism of many organisms and cell types, but the elucidation of the details of its function in a systems biology context has been hampered by the lack of specific high-affinity small-molecule
Katharine J Tuerke et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(40), 13709-13717 (2012-10-05)
A taste associated with emetic drugs produces conditioned disgust reactions in rats (predominantly gaping), unlike nonemetic drugs that can still produce conditioned taste avoidance but not conditioned disgust. That difference suggests nausea is a prerequisite for learning disgust reactions to
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 240931-1G | 04061835554690 |
| 240931-50G | 04061824077995 |