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284270

磷酰基乙酸

Name: 磷酰基乙酸
Brand: ALDRICH

98%

别名:

(羧甲基)膦酸, 2-磷酰基乙酸, 磷酰基乙酸

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关于此项目

线性分子式:

(HO)₂P(O)CH₂CO₂H

化学文摘社编号:

4408-78-0

分子量:

140.03

NACRES:

NA.22

PubChem Substance ID:

24857145

UNSPSC Code:

12352100

EC Number:

224-558-1

MDL number:

MFCD00004311

Assay:

98%

Form:

powder or crystals

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属性

Quality Level

100

assay

98%

form

powder or crystals

mp

143-146 °C (lit.)

solubility

water: soluble 100 mg/mL, clear to very slightly hazy, colorless

functional group

carboxylic acid

SMILES string

OC(=O)CP(O)(O)=O

InChI

1S/C2H5O5P/c3-2(4)1-8(5,6)7/h1H2,(H,3,4)(H2,5,6,7)

InChI key

XUYJLQHKOGNDPB-UHFFFAOYSA-N

说明

General description

膦酰基乙酸可在病毒感染的人成纤维细胞中抑制特异性的人巨细胞病毒DNA合成。它还能够抑制感染细胞中单纯疱疹病毒DNA的合成以及在体外病毒特异性DNA聚合酶的活性。

Application

膦酰基乙酸已被用作病毒DNA复制的一种抑制剂，以研究受感染的低传代牛细胞中感染细胞蛋白0（bICP0）的定位。它还可以磷酸盐非依赖性方式用作微生物生长的一种磷源。

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Phosphate-independent utilization of phosphonoacetic acid as sole phosphorus source by a psychrophilic strain of Geomyces pannorum P15.

Magdalena Klimek-Ochab

Folia microbiologica, 59(5), 375-380 (2014-02-27)

A psychrophilic fungal strain of Geomyces pannorum P15 was screened for its ability to utilize a range of synthetic and natural organophosphonate compounds as the sole source of phosphorus, nitrogen, or carbon. Only phosphonoacetic acid served as a phosphorus source

Herpes simplex virus resistance and sensitivity to phosphonoacetic acid.

R W Honess et al.

Journal of virology, 21(2), 584-600 (1977-02-01)

Phosphonoacetic acid (PAA) inhibited the synthesis of herpes simplex virus DNA in infected cells and the activity of the virus-specific DNA polymerase in vitro. In the presence of concentrations of PAA sufficient to prevent virus growth and virus DNA synthesis

Interaction between the biotin carboxyl carrier domain and the biotin carboxylase domain in pyruvate carboxylase from Rhizobium etli.

Adam D Lietzan et al.

Biochemistry, 50(45), 9708-9723 (2011-10-01)

Pyruvate carboxylase (PC) catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate, an important anaplerotic reaction in mammalian tissues. To effect catalysis, the tethered biotin of PC must gain access to active sites in both the biotin carboxylase domain and the

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全球贸易项目编号

货号	GTIN
284270-50G	04061833545911
284270-10G	04061826253342