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390585

次异羟肟酸

Name: 次异羟肟酸
Brand: ALDRICH

95%

别名:

软木肟酸, SBHA, 辛二酰基双异羟肟酸

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关于此项目

线性分子式:

[-(CH₂)₃CONHOH]₂

化学文摘社编号:

38937-66-5

分子量:

204.22

NACRES:

NA.22

PubChem Substance ID:

24864150

UNSPSC Code:

12352100

MDL number:

MFCD00192455

Assay:

95%

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属性

Quality Level

100

assay

95%

mp

153-155 °C (lit.)

functional group

amine

SMILES string

ONC(=O)CCCCCCC(=O)NO

InChI

1S/C8H16N2O4/c11-7(9-13)5-3-1-2-4-6-8(12)10-14/h13-14H,1-6H2,(H,9,11)(H,10,12)

InChI key

IDQPVOFTURLJPT-UHFFFAOYSA-N

说明

Biochem/physiol Actions

HDAC 抑制剂

软木肟酸(SBHA)是组蛋白脱乙酰基酶（HDAC）抑制剂。SBHA 抑制 HDAC1 和 HDAC3 的活性，IC₅₀ 值分别为 250 和 300 nM。SBHA 抑制增殖，并诱导几种癌细胞系的凋亡。研究表明，SBHA 可激活甲状腺髓样癌（MTC）细胞中的 Notch 信号传导。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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The aim of this study is to explore the efficacy and define mechanisms of action of coadministration of the PI3K/mTOR inhibitor BEZ235 and pan-HDAC inhibitor panobinostat in diffuse large B-cell lymphoma (DLBCL) cells. Various DLBCL cells were exposed to panobinostat

Suberoyl bis-hydroxamic acid activates Notch-1 signaling and induces apoptosis in medullary thyroid carcinoma cells.

Li Ning et al.

The oncologist, 13(2), 98-104 (2008-02-29)

Medullary thyroid carcinoma (MTC) is a neuroendocrine (NE) malignancy that frequently metastasizes and has limited treatments. We recently reported that ectopic expression of Notch-1 in human MTC cells suppresses growth. The objective of this study was to evaluate the ability

A Bim-targeting strategy overcomes adaptive bortezomib resistance in myeloma through a novel link between autophagy and apoptosis.

Shuang Chen et al.

Blood, 124(17), 2687-2697 (2014-09-12)

Bim contributes to resistance to various standard and novel agents. Here we demonstrate that Bim plays a functional role in bortezomib resistance in multiple myeloma (MM) cells and that targeting Bim by combining histone deacetylase inhibitors (HDACIs) with BH3 mimetics

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全球贸易项目编号

货号	GTIN
390585-1G	04061831972672