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Merck
CN

430471

聚(D,L-丙交酯-co-乙交酯)

ester terminated, Mw 50,000-75,000

别名:

Lactel® B6006-1, PLGA

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关于此项目

线性分子式:
[C3H4O2]x[C2H2O2]y
UNSPSC Code:
12162002
PubChem Substance ID:
NACRES:
NA.23
MDL number:
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Quality Level

form

amorphous

feed ratio

lactide:glycolide 85:15

mol wt

Mw 50,000-75,000

degradation timeframe

<6 months

viscosity

0.55-0.75 dL/g, 0.1 % (w/v) in chloroform(25 °C)

transition temp

Tg 45-50 °C

solubility

ethyl acetate, chloroform, acetone and THF: soluble

storage temp.

2-8°C

SMILES string

OCC(O)=O.CC(O)C(O)=O

InChI

1S/C3H6O3.C2H4O3/c1-2(4)3(5)6;3-1-2(4)5/h2,4H,1H3,(H,5,6);3H,1H2,(H,4,5)

InChI key

XBBVURRQGJPTHH-UHFFFAOYSA-N

General description

封端酯基聚(D,L-丙交酯-乙交酯)(PLGA) 的特征特性为 体内 生物降解性、可调谐药物释放特性和极高的包封能力。

Application

PLGA 聚合物用于生产生物可降解医用缝线和控制药物释放。PLGA 微球已被报道用于人生长激素的控制释放。PLGA/聚己内酯/β 组成的共混聚合物薄膜-磷酸三钙已用于引导骨再生。

Features and Benefits

控释生物活性剂、缝线和可生物吸收植入器件。

Physical form

具有生物相容性且可生物降解的聚合物。

Legal Information

Lactel is a registered trademark of Evonik Corp


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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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商品

商业生物材料已停滞不前超过30年的时间,因为很少有材料能够成功地从实验台过渡到临床使用。合成型脂族聚酯因其悠久的历史和获得美国食品药品监督管理局(FDA)批准的记录,一直在可吸收生物材料领域占据主导地位。

In the past two decades, tissue engineering and regenerative medicine have become important interdisciplinary fields that span biology, chemistry, engineering, and medicine.

Innovations in polymer technology have had a significant impact on the advancement of novel drug delivery systems.

查看所有文章

Preparation and characterization of poly (D, L-lactide-co-glycolide) microspheres for controlled release of human growth hormone
Capan Y, et al.
Aaps Pharmscitech, 4(2), 147-156 (2003)
Fabrication of blended polycaprolactone/poly (lactic-co-glycolic acid)/?-tricalcium phosphate thin membrane using solid freeform fabrication technology for guided bone regeneration
Shim JH, et al.
Tissue Engineering: Part A, 19(3-4), 317-328 null
Manjae Gil et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 5(6), 1800024-1800024 (2018-06-26)
Anisotropically compartmentalized microparticles have attracted increasing interest in areas ranging from sensing, drug delivery, and catalysis to microactuators. Herein, a facile method is reported for the preparation of helically decorated microbuilding blocks, using a modified electrohydrodynamic cojetting method. Bicompartmental microfibers



全球贸易项目编号

货号GTIN
430471-1G04061835563029
430471-5G04061835563036