431362
羟胺 盐酸盐
99.999% trace metals basis
别名:
盐酸羟胺
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关于此项目
线性分子式:
NH2OH · HCl
化学文摘社编号:
分子量:
69.49
UNSPSC Code:
12352301
NACRES:
NA.22
PubChem Substance ID:
EC Number:
226-798-2
Beilstein/REAXYS Number:
3539763
MDL number:
Assay:
99.999% trace metals basis
Grade:
ACS reagent (specifications)
grade
ACS reagent (specifications)
Quality Level
assay
99.999% trace metals basis
form
crystals
impurities
≤0.005% S compounds, ≤0.25 meq/g Titr. free acid, <10 ppm total metallic impurities
ign. residue
≤0.05%
pH
2.5-3.5 (20 °C, 50 g/L)
mp
155-157 °C (dec.) (lit.)
density
1.67 g/mL at 25 °C (lit.)
cation traces
Fe: ≤5 ppm, NH4+:, passes test, heavy metals: ≤5 ppm
SMILES string
Cl.NO
InChI
1S/ClH.H3NO/c;1-2/h1H;2H,1H2
InChI key
WTDHULULXKLSOZ-UHFFFAOYSA-N
Application
制备反应物：
- 有机硅烷胺作为甲型流感病毒 M2 质子通道的有效抑制剂和结构探针
- Lamellarin D 类似物作为拓扑异构酶 I 的抑制剂和潜在的抗肿瘤剂
- Azapeptide 宫缩抑制剂作为前列腺素 F2a 受体的抑制剂，用于预防早产
- 与吲哚啉-2-酮螺旋稠合的噻唑烷酮作为结核分枝杆菌蛋白酪氨酸磷酸酶 B 的有效和选择性抑制剂
- 基于口服生物可利用的基于喹啉的抗糖尿病二肽基肽酶 IV 抑制剂，靶向 Lys554
- 嘧啶核苷衍生物与一氧化氮供体，作为抗病毒剂
- 苄基腺苷化合物靶向腺苷 A2A 受体和腺苷转运蛋白，用于神经保护
- 萘酚衍生物作为香草素受体 TRPV1 的抑制剂，在尿失禁的大鼠膀胱测压模型中具有改善的效力
Biochem/physiol Actions
MAO 抑制剂;抑制血小板聚集。
Features and Benefits
符合 A.C.S. 的试剂规范。
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signalword
Warning
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Carc. 2 - Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 Oral
target_organs
spleen
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
存储类别
8B - Non-combustible corrosive hazardous materials
Carine B Bourguet et al.
Journal of medicinal chemistry, 54(17), 6085-6097 (2011-07-22)
The prostaglandin-F2α (PGF2α) receptor (FP) was targeted to develop tocolytic agents for inhibiting preterm labor. Azabicycloalkane and azapeptide mimics 2-10 were synthesized based on the (3S,6S,9S)-indolizidin-2-one amino acid analogue PDC113.824 (1), which was shown to modulate FP by a biased
Salvatore Cananzi et al.
Bioorganic & medicinal chemistry, 19(16), 4971-4984 (2011-07-26)
A novel 5-oxa-6a,8-diazaindeno[2,1-b]phenanthren-7-one scaffold was designed and synthesized as an active analogue of the cytotoxic marine alkaloid Lamellarin D. The design was based on molecular modeling of the site of interaction of Lamellarin D with DNA-topoisomerase I cleavable complex, whereas
Jun Wang et al.
Journal of the American Chemical Society, 133(35), 13844-13847 (2011-08-09)
We describe the use of organosilanes as inhibitors and structural probes of a membrane protein, the M2 proton channel from influenza A virus. Organosilane amine inhibitors were found to be generally as potent as their carbon analogues in targeting WT
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 431362-250G | 04061832108254 |
| 431362-50G | 04061832108261 |