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Merck
CN

47622

Fmoc-Thr(tBu)-OH

≥98.0% (HPLC), for peptide synthesis

别名:

Fmoc-O-叔丁基-L-苏氨酸

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关于此项目

经验公式(希尔记法):
C23H27NO5
化学文摘社编号:
分子量:
397.46
NACRES:
NA.26
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352209
EC Number:
276-261-1
MDL number:
Beilstein/REAXYS Number:
4581133
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产品名称

Fmoc-Thr(tBu)-OH, ≥98.0% (HPLC)

Quality Level

assay

≥98.0% (HPLC)

optical activity

[α]20/D +16±1°, c = 1% in ethyl acetate

reaction suitability

reaction type: C-H Activation, reaction type: Fmoc solid-phase peptide synthesis, reagent type: ligand
reaction type: Peptide Synthesis

application(s)

peptide synthesis

functional group

Fmoc, amine, carboxylic acid

storage temp.

2-8°C

SMILES string

C[C@@H](OC(C)(C)C)[C@H](NC(=O)OCC1c2ccccc2-c3ccccc13)C(O)=O

InChI

1S/C23H27NO5/c1-14(29-23(2,3)4)20(21(25)26)24-22(27)28-13-19-17-11-7-5-9-15(17)16-10-6-8-12-18(16)19/h5-12,14,19-20H,13H2,1-4H3,(H,24,27)(H,25,26)/t14-,20+/m1/s1

InChI key

LZOLWEQBVPVDPR-VLIAUNLRSA-N

General description

Fmoc-Thr(tBu)-OH也称为Fmoc-O-叔丁基-L-苏氨酸,常用作多肽合成中的氨基酸合成砌块。

Application

Fmoc-Thr(tBu)-OH可用于通过固相多肽合成反应合成chlorofusin类似物。此外,在复杂的缩酚酸肽(depsipeptide)固相合成中,可作为胺和羟基的保护基。


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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Zdenek Kukacka et al.
ChemMedChem, 13(9), 909-915 (2018-02-24)
α-Galactosidase (αGal) is a lysosomal enzyme that hydrolyses the terminal α-galactosyl moiety from glycosphingolipids. Mutations in the encoding genes for αGal lead to defective or misfolded enzyme, which results in substrate accumulation and subsequent organ dysfunction. The metabolic disease caused
Stefan Eissler et al.
Journal of peptide science : an official publication of the European Peptide Society, 23(10), 757-762 (2017-06-22)
In solid-phase peptide synthesis, the nominal batch size is calculated using the starting resin substitution and the mass of the starting resin. The starting resin substitution constitutes the basis for the calculation of a whole set of important process parameters



全球贸易项目编号

货号GTIN
47622-1KG-F04061826222676
47622-100G-F04061832362168
47622-10G-F04061832362175
47622-1G-F04061826222669
47622-25G-F04061832642550