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关于此项目
经验公式(希尔记法):
C24H27NO6
化学文摘社编号:
分子量:
425.47
NACRES:
NA.26
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352209
EC Number:
276-253-8
MDL number:
Beilstein/REAXYS Number:
3636375
产品名称
芴甲氧羰酰-色氨酸, ≥98.0% (HPLC)
assay
≥98.0% (HPLC)
form
powder
optical activity
[α]20/D −5.0±2.0°, c = 1% in acetic acid: water (4:1)
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
impurities
~4% water
application(s)
peptide synthesis
functional group
Fmoc
storage temp.
2-8°C
SMILES string
CC(C)(C)OC(=O)CC[C@H](NC(=O)OCC1c2ccccc2-c3ccccc13)C(O)=O
InChI
1S/C24H27NO6/c1-24(2,3)31-21(26)13-12-20(22(27)28)25-23(29)30-14-19-17-10-6-4-8-15(17)16-9-5-7-11-18(16)19/h4-11,19-20H,12-14H2,1-3H3,(H,25,29)(H,27,28)/t20-/m0/s1
InChI key
OTKXCALUHMPIGM-FQEVSTJZSA-N
General description
Fmoc-Glu(OtBu)-OH 被广泛用于肽合成中保护胺基的合成嵌段。
Application
Fmoc-Glu(OtBu)-OH(氧羰基-L-谷氨酸 5-叔-丁酯)可用于:
还可用作基本构成要素制备钉状α-螺旋肽和肽C-端硫代酸酯。
- 配体,以使用Pd催化剂通过环丙烷酰胺C-H活化反应合成顺式取代环丙烷羧酸。
- 多小分子共轭PTX(紫杉醇)衍生物制备中的连接剂。
还可用作基本构成要素制备钉状α-螺旋肽和肽C-端硫代酸酯。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Solid phase synthesis of peptide C-terminal thioesters by Fmoc/t-Bu chemistry
Ingenito R, et al.
Journal of the American Chemical Society, 121(49), 11369-11374 (1999)
Multi-small molecule conjugations as new targeted delivery carriers for tumor therapy
Shan L, et al.
International journal of nanomedicine, 10(49), 5571-5571 (2015)
Stapled α-helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy
Chang YS, et al.
Proceedings of the National Academy of Sciences of the USA, 110(36), E3445-E3454 (2013)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 47625-25G | 04061832362281 |
| 47625-100G | 04061832362267 |
| 47625-10G | 04061832362274 |
| 47625-1KG | 04061826222713 |