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739979

Resomer® RG 858 S，聚(D,L-丙交酯-共-乙交酯)

ester terminated, lactide:glycolide 85:15, Mw 190,000-240,000

别名:

PLGA

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关于此项目

线性分子式:
[C3H4O2]x[C2H2O2]y
化学文摘社编号:
26780-50-7
MDL number:
MFCD00131930
UNSPSC Code:
12162002
NACRES:
NA.23
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Quality Level

100

form

amorphous

feed ratio

lactide:glycolide 85:15

mol wt

Mw 190,000-240,000

degradation timeframe

<9 months

viscosity

1.3-1.7 dL/g, 0.1 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer)

storage temp.

2-8°C

SMILES string

O2C(C(=O)OC(C2=O)C)C.O1CC(=O)OCC1=O

InChI

1S/C6H8O4.C4H4O4/c1-3-5(7)10-4(2)6(8)9-3;5-3-1-7-4(6)2-8-3/h3-4H,1-2H3;1-2H2

InChI key

LCSKNASZPVZHEG-UHFFFAOYSA-N

General description

RESOMER®聚合物是生物可吸收的脂肪族聚酯，它由一系列不同比例的丙交酯和乙交酯单体、PLA立体化学和端基官能化组成。这些丙交酯和乙交酯的生物可降解均聚物和共聚物具有多种特性，其范围从降解时间长的刚性硬质半晶体材料到降解速率更快、更软的无定形材料。

Application

Electrospun Resomer® X 206 S与来自甘蔗渣的纤维素混合，可用作组织工程中的支架。
控制释放

Features and Benefits

生物活性剂的控制释放、缝合线和生物可吸收性可植入装置。

Legal Information

Evonik产品
RESOMER is a registered trademark of Evonik Rohm GmbH

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCG7417
BCCF7604
BCCC6904
BCBV9308
BCCB3648

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商业生物材料已停滞不前超过30年的时间，因为很少有材料能够成功地从实验台过渡到临床使用。合成型脂族聚酯因其悠久的历史和获得美国食品药品监督管理局（FDA）批准的记录，一直在可吸收生物材料领域占据主导地位。

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RESOMER??Biodegradeable Polymers for Sutures, Medical Devices, Drug Delivery Systems and Tissue Engineering
Mader K
Material Matters, 6(3), 62-62 (2011)
Rongcai Liang et al.
International journal of pharmaceutics, 454(1), 344-353 (2013-07-23)
Peptide or protein degradation often occurs when water flows into the dosage form. The aim of this study was to investigate the effect of water on exenatide acylation in poly(lactide-co-glycolide) (PLGA) microspheres. Exenatide-loaded PLGA microspheres were incubated at different relative
Shu-Chun Chuang et al.
Parasites & vectors, 6, 34-34 (2013-02-13)
Current development efforts of subunit vaccines against Toxoplasma gondii, the etiological agent of toxoplasmosis, have been focused mainly on tachyzoite surface antigen 1 (SAG1). Since microparticles made from poly (lactide-co-glycolide) (PLG) polymers have been developed as safe, potent adjuvants or
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全球贸易项目编号

货号GTIN
739979-1G04061832884202
739979-5G04061832884219