产品名称
2-二环己基膦基-2′,6′-二甲氧基联苯基, 95%
assay
95%
form
powder or crystals
reaction suitability
reaction type: Buchwald-Hartwig Cross Coupling Reaction, reaction type: Heck Reaction, reaction type: Hiyama Coupling, reaction type: Negishi Coupling, reaction type: Sonogashira Coupling, reaction type: Stille Coupling, reaction type: Suzuki-Miyaura Coupling, reagent type: catalyst
reaction type: Cross Couplings, reagent type: ligand
greener alternative product characteristics
Catalysis
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sustainability
Greener Alternative Product
mp
164-166 °C (lit.), 165.5 °C
functional group
phosphine
greener alternative category
General description
SPhos [2-Dicyclohexylphosphino-2′, 6′-dimethoxybiphenyl] is an air-stable, electron-rich biaryl phosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions.
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Application
用于Suzuki-Miyaura偶联反应的高度通用配体； 芳基氯、受阻联芳基、杂联芳基。
SPhos may be used as a ligand in the following processes:
- Palladium catalyzed Suzuki-Miyaura cross-coupling reaction between Boc-protected aminomethyltrifluoroborate and aryl chlorides or hetaryl chlorides to form the corresponding aminomethylarenes.
- Palladium catalyzed Suzuki-Miyaura cross-coupling reaction between 4-methyl-substituted piperidinylzinc reagent and different aryl or heteroaryl iodides to form various substituted piperidines.
- Intramolecular Suzuki-Miyaura coupling to form the 18-membered macrocyclic ring during the multi-step synthesis of riccardin C.
Utilized in conjunction with palladium to form a highly active catalyst for C-N bond formation
Legal Information
使用涉及的专利号：US 6307087；EP 1097158；JP 5758844；CA 2336691
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Synthesis of riccardin C and its seven analogues. Part 1: The role of their phenolic hydroxy groups as LXRa agonists.
Hioki H, et al.
Bioorganic & Medicinal Chemistry Letters, 19(3), 738-741 (2009)
Seel S, et al.
Journal of the American Chemical Society, 133(13), 4774-4777 (2011)
Synthesis and Suzuki?Miyaura Cross-Coupling Reactions of Potassium Boc-Protected Aminomethyltrifluoroborate with Aryl and Hetaryl Halides
Molander, Gary A., and Inji Shin.
Organic Letters, 13.15, 3956-3959 (2011)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 901906-1G | 04061835511150 |
| 901906-250G | 04061835519859 |
| 901906-25G | 04061835559947 |
| 901906-5G | 04061835511181 |