907251
H-L-Photo-lysine HCl
≥98%
别名:
(S)-2-Amino-6-((2-(3-methyl-3H-diazirin-3-yl)ethoxy)carbonylamino)hexanoic acid hydrochloride, (S)-2-Amino-6-((2-(3H-diazirin-3-yl)propoxy)carbonylamino)hexanoic acid hydrochloride, 3′-Azibutyl-N-carbamoyl-lysine hydrochloride, Abk, Diazirine amino acid, Photo-Lys, Photo-crosslinking amino acid, Photoprobe building block
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关于此项目
经验公式（希尔记法）:
C11H21ClN4O4
化学文摘社编号:
分子量:
308.76
MDL number:
UNSPSC Code:
12352209
NACRES:
NA.26
assay
≥98%
form
powder
reaction suitability
reaction type: solution phase peptide synthesis
availability
available only in USA
application(s)
peptide synthesis
storage temp.
−20°C
SMILES string
N[C@@H](CCCCNC(=O)OCCC1(N=N1)C)C(=O)O
InChI
1S/C11H20N4O4/c1-11(14-15-11)5-7-19-10(18)13-6-3-2-4-8(12)9(16)17/h8H,2-7,12H2,1H3,(H,13,18)(H,16,17)/t8-/m0/s1
InChI key
LUCMNTLJAFTFDU-QMMMGPOBSA-N
Application
H-L-Photo-lysine HCl is a diazirine-containing lysine amino acid and multifunctional probe building blocks. Its incorporation into peptides or small-molecule probes and tools allows for photoaffinity labeling of cellular targets and protein-protein interactions upon UV light (~360 nm) irradiation to form a covalent bond. This and other multifunctional probe building blocks will continue to accelerate drug discovery research for probing cellular mechanisms, target ID/validation, and understanding traditionally undruggable targets. An Fmoc-protected version is also available as 907383.
Product can be used with our line of photoreactors: Including Penn PhD (Z744035) & SynLED 2.0 (Z744080)
Product can be used with our line of photoreactors: Including Penn PhD (Z744035) & SynLED 2.0 (Z744080)
Other Notes
A Bifunctional Noncanonical Amino Acid: Synthesis, Expression, and Residue-Specific Proteome-wide Incorporation
Genetically Encoded 2-Aryl-5-carboxytetrazoles for Site-Selective Protein Photo-Cross-Linking</A
Genetic code expansion for multiprotein complex engineering
Efficient viral delivery system for unnatural amino acid mutagenesis in mammalian cells
Probing Protein-Protein Interactions with a Genetically Encoded Photo-crosslinking Amino Acid
Fishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe Synthesis
Photo-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs)
Genetically Encoded 2-Aryl-5-carboxytetrazoles for Site-Selective Protein Photo-Cross-Linking</A
Genetic code expansion for multiprotein complex engineering
Efficient viral delivery system for unnatural amino acid mutagenesis in mammalian cells
Probing Protein-Protein Interactions with a Genetically Encoded Photo-crosslinking Amino Acid
Fishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe Synthesis
Photo-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs)
flash_point_f
Not applicable
flash_point_c
Not applicable
存储类别
4.1B - Flammable solid hazardous materials
法规信息
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 907251-100MG | 04022536043081 |