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913669

Biotinamidoethyldisulfanyl(2-aminoethane) trifluoroacetic acid

Name: Biotinamidoethyldisulfanyl(2-aminoethane) trifluoroacetic acid
Brand: ALDRICH

别名:

N-(2-((2-Aminoethyl)disulfaneyl)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide 2,2,2-trifluoroacetate, Biotin-SS-NH₂ TFA, Biotin-cystamine TFA, Cleavable biotin linker

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关于此项目

经验公式（希尔记法）:

C₁₆H₂₇F₃N₄O₄S₃

化学文摘社编号:

880491-09-8

分子量:

492.60

MDL number:

MFCD34166204

UNSPSC Code:

12352106

NACRES:

NA.22

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属性

form

powder

Quality Level

100

storage temp.

−20°C

SMILES string

OC(C(F)(F)F)=O.NCCSSCCNC(CCCC[C@H]1[C@]2([H])[C@](NC(N2)=O)([H])CS1)=O

InChI

1S/C14H26N4O2S3.C2HF3O2/c15-5-7-22-23-8-6-16-12(19)4-2-1-3-11-13-10(9-21-11)17-14(20)18-13;3-2(4,5)1(6)7/h10-11,13H,1-9,15H2,(H,16,19)(H2,17,18,20);(H,6,7)/t10-,11-,13-;/m0./s1

InChI key

IEBCHCOZFAGWJW-SQRKDXEHSA-N

说明

Application

Biotinamidoethyldisulfanyl(2-aminoethane) trifluoroacetic acid (Biotin-SS-NH₂ TFA) is a cleavable, biotinylated crosslinkers. The linker can also be used for synthesis of chemical biology tools for labeling target proteins in biological experiments and assays. It possesses dual functionality: enrichment via the biotin and an embedded disulfide bridge for cleavage under reducing conditions.

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Other Notes

Fluorometric assay for tissue transglutaminase-mediated transamidation activity

Convenient Synthesis of Photoaffinity Probes and Evaluation of Their Labeling Abilities

A simple photo-affinity labeling protocol

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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分析证书(COA)

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Convenient synthesis of photoaffinity probes and evaluation of their labeling abilities.

Toshiyuki Kan et al.

Organic letters, 9(11), 2055-2058 (2007-05-08)

Convenient synthesis of a variety of photoaffinity probes was accomplished by utilizing our Ns strategy and novel resin. The synthetic probes were evaluated via the labeling ability with the preseniline 1 C-terminal fragments, which was identified as a therapeutic target

Fluorometric assay for tissue transglutaminase-mediated transamidation activity.

Claudio Gnaccarini et al.

Bioorganic & medicinal chemistry, 17(17), 6354-6359 (2009-08-08)

Herein, we report the development of a direct discontinuous fluorometric transamidation assay for determining tissue transglutaminase (TG2) activity. In the assay reaction, TG2 catalyzes the formation of a biotin-fluorophore conjugate, using a fluorescent, high affinity gamma-glutamyl donor substrate and a

全球贸易项目编号

货号	GTIN
913669-50MG	04061842082797