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Merck
CN

927465

BMK-alkyne

别名:

1-Bromohept-6-yn-2-one

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关于此项目

经验公式(希尔记法):
C7H9BrO
分子量:
189.05
UNSPSC Code:
12352101
NACRES:
NA.22
MDL number:
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form

liquid

Quality Level

refractive index

n/D 1.494

density

1.368

storage temp.

−20°C

SMILES string

BrCC(=O)CCCC#C

InChI

1S/C7H9BrO/c1-2-3-4-5-7(9)6-8/h1H,3-6H2

InChI key

SLVASQVSQAKKMN-UHFFFAOYSA-N

Application

BMK-alkyne is a probe that can be used for labeling cysteines through alkylation. A method was developed using cysteine-reactive compounds including this one to allow for unbiased analysis of proteomic data in quantitave applications (Zanon et al. 2021). The method uses light or heavy labeling with the isotopically labelled desthiobiotin azide (isoDTB) tag for mass spectrometry analysis (Zanon et al. 2020). Analysis then uses the isotopic tandem orthogonal proteolysis activity-based protein profiling (isoTOP-ABPP) workflow (Weerapana et al. 2010, Backus et al. 2016).


wgk

WGK 3

存储类别

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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Isotopically Labeled Desthiobiotin Azide (isoDTB) Tags Enable Global Profiling of the Bacterial Cysteinome
Zanon, et al
Angewandte Chemie (International Edition in English), 2829-2836 (2020)



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货号GTIN
927465-50MG04065268021866