929441
C5-Pomalidomide-piperazine hydrochloride
≥95%
别名:
2-(2,6-Dioxopiperidin-3-yl)-5-(piperazin-1-yl)isoindoline-1,3-dione hydrochloride
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关于此项目
经验公式（希尔记法）:
C17H18N4O4 · xHCl
化学文摘社编号:
分子量:
342.35 (free base basis)
UNSPSC Code:
12352101
NACRES:
NA.21
MDL number:
ligand
pomalidomide
Quality Level
assay
≥95%
form
powder
storage temp.
2-8°C
SMILES string
O=C1N(C2CCC(NC2=O)=O)C(C3=CC=C(N4CCNCC4)C=C31)=O
InChI key
GFCKACFUYUKAPW-UHFFFAOYSA-N
Application
Protein degrader building block C5-Pomalidomide-piperazine hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC® (proteolysis-targeting chimeras) research. This conjugate contains a Cereblon (CRBN) recruiting ligand, a rigid linker, and a nitroveratryloxycarbonyl group that can undergo photolysis to form a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate degrader libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
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Other Notes
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
signalword
Danger
hcodes
Hazard Classifications
Repr. 1B
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 929441-50MG | 04065268523827 |