943517
(R)-1-(3-Aminophenyl)-3-(3,4-dimethoxyphenyl)propyl (S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate
≥95%
别名:
(1R)-1-(3-aminophenyl)-3-(3,4-dimethoxyphenyl)propyl ester, (2S)- ; (1R)-1-(3-Aminophenyl)-3-(3,4-dimethoxyphenyl)propyl (2S)-1-(3,3-dimethyl-1,2-dioxopentyl)-2-piperidinecarboxylate;, 1-(3,3-dimethyl-1,2-dioxopentyl)-, 2-Piperidinecarboxylic acid, AP 3351
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关于此项目
Assay:
≥95%
Form:
solid
Quality Level
assay
≥95%
form
solid
functional group
amine
storage temp.
2-8°C
SMILES string
O=C(OC(C=1C=CC=C(N)C1)CCC2=CC=C(OC)C(OC)=C2)C3N(C(=O)C(=O)C(C)(C)CC)CCCC3
InChI
1S/C30H40N2O6/c1-6-30(2,3)27(33)28(34)32-17-8-7-12-23(32)29(35)38-24(21-10-9-11-22(31)19-21)15-13-20-14-16-25(36-4)26(18-20)37-5/h9-11,14,16,18-19,23-24H,6-8,12-13,15,17,31H2,1-5H3/t23-,24+/m0/s1
InChI key
IIDSDBBDZNDWCN-BJKOFHAPSA-N
General description
SLF (Synthetic Ligand of FKBP) is a small-molecule ligand designed to bind FKBP12 and related FK506-binding proteins. It mimics immunosuppressant binding (like FK506/rapamycin) but is non-immunosuppressive, making it useful as a chemical biology tool in studies of protein interactions and targeted protein degradation (e.g., PROTAC designs).
Application
- Chemical biology & target validation: Studies of FKBP function and protein complex formation.
- PROTAC synthesis: Serves as an FKBP-binding “warhead” or recruiting moiety in degrader constructs.
- Protein–protein interaction modulation: Used to stabilize or disrupt FKBP-mediated interactions.
Features and Benefits
- Selective FKBP binder: Engages FKBP proteins, enabling modulation or recruitment in biological systems.
- Useful in PROTAC/chemical dimerizer designs: Acts as a recruitment handle to bring FKBP-tagged target proteins into proximity with ligases or partners.
- Versatile research reagent: Applicable in cell-based assays, protein interaction studies, and probe development.
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 943517-5MG | 04065274057392 |