主要文件

查看所有文档

F6562

Fmoc-(R)-2-(7-octenyl)Ala-OH

Name: Fmoc-(<I>R</I>)-2-(7-octenyl)Ala-OH
Brand: ALDRICH

for peptide synthesis

别名:

(R)-N-Fmoc-α-(7-Octenyl)alanine, Fmoc-(R)-2-(7-octenyl)alanine, Fmoc-(R)-2-amino-2-methyl-dec-6-enoic acid

登录查看组织和合同定价。

选择尺寸

变更视图

关于此项目

经验公式（希尔记法）:

C₂₆H₃₁NO₄

化学文摘社编号:

945212-26-0

分子量:

421.53

UNSPSC Code:

12352209

PubChem Substance ID:

329799756

NACRES:

NA.26

MDL number:

MFCD12925761

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

属性

产品名称

Fmoc-(R)-2-(7-octenyl)Ala-OH,

form

solid

Quality Level

200

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

application(s)

peptide synthesis

functional group

Fmoc

storage temp.

−20°C

SMILES string

O=C(OCC1C(C=CC=C2)=C2C3=C1C=CC=C3)N[C@@](CCCCCCC=C)(C)C(O)=O

InChI

1S/C26H31NO4/c1-3-4-5-6-7-12-17-26(2,24(28)29)27-25(30)31-18-23-21-15-10-8-13-19(21)20-14-9-11-16-22(20)23/h3,8-11,13-16,23H,1,4-7,12,17-18H2,2H3,(H,27,30)(H,28,29)/t26-/m1/s1

InChI key

MADFVGMQNXRFAF-AREMUKBSSA-N

说明

Application

Olefinic alpha-methyl amino acid for peptide stapling. Upon incorporation of this amino acid into a peptide, along with another of the same or derivative with a different length of the olefinic side chain, the two can be ′stapled′ via a ring closing metathesis reaction with Grubb′s catalyst (product # 579726). The resulting stapled peptide macrocycle has been shown to stabilize the alpha-helical structure of peptides, which can lead to favorable biological characteristics such as increased proteolytic stability and cellular uptake.

pictograms

GHS09

signalword

Warning

hcodes

H400

pcodes

P273 - P391 - P501

Hazard Classifications

Aquatic Acute 1

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

新产品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Synthesis of all-hydrocarbon stapled α-helical peptides by ring-closing olefin metathesis.

Young-Woo Kim et al.

Nature protocols, 6(6), 761-771 (2011-06-04)

This protocol provides a detailed procedure for the preparation of stapled α-helical peptides, which have proven their potential as useful molecular probes and as next-generation therapeutics. Two crucial features of this protocol are (i) the construction of peptide substrates containing

Assessing the Efficacy of Mdm2/Mdm4-Inhibiting Stapled Peptides Using Cellular Thermal Shift Assays.

Ban Xiong Tan et al.

Scientific reports, 5, 12116-12116 (2015-07-15)

Previous publications on stapled peptide inhibitors against Mdm2/Mdm4-p53 interactions have established that this new class of drugs have the potential to be easily optimised to attain high binding affinity and specificity, but the mechanisms controlling their cellular uptake and target

全球贸易项目编号

货号	GTIN
F6562-1G	04061826097380
F6562-5G	04061832597805