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Merck
CN

P55805

嘌呤

98%

别名:

7H-咪唑[4,5-d]嘧啶

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关于此项目

经验公式(希尔记法):
C5H4N4
化学文摘社编号:
分子量:
120.11
UNSPSC Code:
12352005
NACRES:
NA.22
PubChem Substance ID:
EC Number:
204-421-2
Beilstein/REAXYS Number:
3200
MDL number:
Assay:
98%
Form:
powder
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Quality Level

assay

98%

form

powder

mp

214-217 °C (lit.)

SMILES string

c1ncc2nc[nH]c2n1

InChI

1S/C5H4N4/c1-4-5(8-2-6-1)9-3-7-4/h1-3H,(H,6,7,8,9)

InChI key

KDCGOANMDULRCW-UHFFFAOYSA-N

General description

嘌呤是一种杂环有机化合物,由一个嘧啶环与一个咪唑环融合而成。

Application

在钯催化剂存在时,嘌呤可直接进行 C-H 功能化,形成各种生物学重要产品。


存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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New developments in direct functionalization of C-H and N-H bonds of purine bases via metal catalyzed cross-coupling reactions.
Abdoli M, et al.
Royal Society of Chemistry Advances, 55(5), 44371-44389 (2015)
Benshang Li et al.
Nature medicine, 21(6), 563-571 (2015-05-12)
Relapse is the leading cause of mortality in children with acute lymphoblastic leukemia (ALL). Among chemotherapeutics, thiopurines are key drugs in ALL combination therapy. Using whole-exome sequencing, we identified relapse-specific mutations in the phosphoribosyl pyrophosphate synthetase 1 gene (PRPS1), which
Silvia Meneghesso et al.
ChemMedChem, 8(3), 415-425 (2013-02-07)
2'-Fluoro-2'-deoxyguanosine has been reported to have potent anti-influenza virus activity in vitro and in vivo. Herein we describe the synthesis and biological evaluation of 6-modified 2'-fluoro-2'-deoxyguanosine analogues and their corresponding phosphoramidate ProTides as potential anti-influenza virus agents. Whereas the parent



全球贸易项目编号

货号GTIN
P55805-1G04061834391982