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P57204

哒嗪

Name: 哒嗪
Brand: ALDRICH

98%

别名:

1,2-二氮杂苯, 1,2-噻嗪, 邻噻嗪

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关于此项目

经验公式（希尔记法）:

C₄H₄N₂

化学文摘社编号:

289-80-5

分子量:

80.09

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24898697

EC Number:

206-025-5

Beilstein/REAXYS Number:

103906

MDL number:

MFCD00006463

Assay:

98%

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属性

Quality Level

100

assay

98%

refractive index

n20/D 1.524 (lit.)

bp

208 °C (lit.)

mp

−8 °C (lit.)

density

1.103 g/mL at 25 °C (lit.)

SMILES string

c1ccnnc1

InChI

1S/C4H4N2/c1-2-4-6-5-3-1/h1-4H

InChI key

PBMFSQRYOILNGV-UHFFFAOYSA-N

说明

General description

哒嗪是一种单碱式1,2-二嗪化合物，通常可通过1,4-二羰基与肼反应进行制备。哒嗪环存在于如克雷达嗪、吡哆醇等多种除草剂，以及如头孢唑仑、奥拉帕利、他拉唑帕利和卡达拉嗪等多种药物中。

Application

哒嗪可用于：

作为构建单元，用于合成可作为GSK-3抑制剂的N-苯基-4-吡唑并[1,5-b]哒嗪-3-基-嘧啶-2-胺衍生物。
作为合成具有重要药用价值的吡咯并[1,2-b]哒嗪衍生物的起始材料。
在酸性条件下制备可作为钢铁缓蚀剂的1-（6-乙氧基-6-氧代己基）哒嗪-1-溴化铵和1-（2-溴乙酰基）哒嗪溴化铵离子液体。

存储类别

10 - Combustible liquids

wgk

WGK 3

flash_point_f

185.0 °F - closed cup

flash_point_c

85 °C - closed cup

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

历史批次信息供参考:

分析证书(COA)

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Hydrogen bonding and reactivity of water to azines in their S1 (n,π*) electronic excited states in the gas phase and in solution.

Jeffrey R Reimers et al.

Physical chemistry chemical physics : PCCP, 14(25), 8791-8802 (2012-04-26)

A unified picture is presented of water interacting with pyridine, pyridazine, pyrimidine, and pyrazine on the S(1) manifold in both gas-phase dimers and in aqueous solution. As (n,π*) excitation to the S(1) state removes electrons from the ground-state hydrogen bond

Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors.

Emily A Peterson et al.

Bioorganic & medicinal chemistry letters, 22(15), 4967-4974 (2012-07-07)

mTOR is a critical regulator of cellular signaling downstream of multiple growth factors. The mTOR/PI3K/AKT pathway is frequently mutated in human cancers and is thus an important oncology target. Herein we report the evolution of our program to discover ATP-competitive

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全球贸易项目编号

货号	GTIN
P57204-50G	04061833452677
P57204-5G	04061834392279